Investigation into the effect of neoadjuvant therapy and tumor regression grade on the shrinkage of distal surgical margin in rectal cancer: A prospective case-control study

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dc.contributor.authorAday, Ulas
dc.contributor.authorKilicarslan, Ahmet
dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorAkkoc, Hasan
dc.date.accessioned2024-04-24T17:24:14Z
dc.date.available2024-04-24T17:24:14Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The present study aimed to explore the effect of neoadjuvant therapy and tumor regression grade (TRG) on the shrinkage in the distal surgical margin ( DSM) induced by formalin fixation in rectal cancer. Materials and Methods: In this prospective study, the DSM of resected 61 specimens of rectal and rectosigmoid junction adenocarcinoma were measured following fresh and formalin fixation. The measurements were performed within the first 15 min after resection and at 24 h after formalin fixation without pinning and were compared with regard to neoadjuvant treatment status and TRG. Results: In the patients that received neoadjuvant therapy, the fresh and postfixation DSM values were 32.2 mm and 22.7 mm, respectively, and the mean shrinkage rate was 34.7% (P. 0.001). In the patients that did not receive neoadjuvant therapy, the fresh and postfixation DSM values were 54.03 mm and 41.9 mm, respectively, and the mean shrinkage rate was 23.7% (P. 0.001). The mean shrinkage rate was 41.9% in TRG 1, 29.4% in TRG 2, and 31.9 in TRG 3 specimens. The mean shrinkage rate was higher in specimens with a DSM of =20 mm compared to specimens with a DSM of >20 mm (46.2% vs. 24.9%). Conclusion: A complete or near-complete tumor regression in patients with rectal cancer undergoing neoadjuvant therapy increases the shrinkage of DSM. Moreover, this shrinkage rate is likely to be higher and the pathological DSM is likely to be closer than expected in cases that present a better clinical response to neoadjuvant therapy, particularly in distal rectal cancer.en_US
dc.identifier.doi10.4103/IJPM.IJPM_1130_20
dc.identifier.endpage348en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.issue2en_US
dc.identifier.pmid35435369
dc.identifier.scopus2-s2.0-85128372870
dc.identifier.scopusqualityQ3
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.4103/IJPM.IJPM_1130_20
dc.identifier.urihttps://hdl.handle.net/11468/19552
dc.identifier.volume65en_US
dc.identifier.wosWOS:000876353700017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Pathology and Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDistal Surgical Marginen_US
dc.subjectNeoadjuvant Therapyen_US
dc.subjectRectal Canceren_US
dc.subjectTumor Regression Gradeen_US
dc.titleInvestigation into the effect of neoadjuvant therapy and tumor regression grade on the shrinkage of distal surgical margin in rectal cancer: A prospective case-control studyen_US
dc.titleInvestigation into the effect of neoadjuvant therapy and tumor regression grade on the shrinkage of distal surgical margin in rectal cancer: A prospective case-control study
dc.typeArticleen_US

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