Oxidative stress parameters in children with acute rheumatic fever

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dc.contributor.authorPirinccioglu, Ayfer Gozu
dc.contributor.authorAlyan, Omer
dc.contributor.authorAkin, Alper
dc.contributor.authorKizil, Goksel
dc.contributor.authorIsik, Fatma Birgul
dc.date.accessioned2024-04-24T17:11:49Z
dc.date.available2024-04-24T17:11:49Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground The aim of this study was to investigate of the role of oxidative stress (OS) in acute rheumatic fever (ARF) and its relationship with the progress of the disease. Methods Thirty patients with ARF and 31 age-sex-matched healthy children were enrolled in this study. Serum malondialdehyde (MDA), protein carbonyl (PCO), high-sensitivity C-reactive protein (hs-CRP), cytokines (tumor necrosis factor-alpha and interleukin-6) and total antioxidant capacity (TAC) were measured. The diagnosis of ARF was based on the Jones criteria. Results Patients with ARF had significantly higher serum MDA, PCO, hs-CRP and cytokine levels and lower TAC than healthy controls. On Pearson's correlation analysis we found that oxidative stress markers were positively correlated with hs-CRP and cytokines, while TAC was negatively correlated with MDA, PCO, hs-CRP and cytokines. The number of valves involved as well as the level of mitral valve involvement was also significantly related to the oxidative stress parameters and TAC. All oxidative stress parameters decreased significantly with anti-inflammatory therapy while TAC increased. Conclusion Malondialdehyde and PCO, as biomarkers, as well as hs-CRP together with the other available diagnostic tools, can be used in the evaluation of patients with ARF.en_US
dc.identifier.doi10.1111/ped.13983
dc.identifier.endpage966en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue10en_US
dc.identifier.pmid31332885
dc.identifier.scopus2-s2.0-85074202832
dc.identifier.scopusqualityQ3
dc.identifier.startpage962en_US
dc.identifier.urihttps://doi.org/10.1111/ped.13983
dc.identifier.urihttps://hdl.handle.net/11468/17735
dc.identifier.volume61en_US
dc.identifier.wosWOS:000493117000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Rheumatic Feveren_US
dc.subjectLipid Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectProtein Oxidationen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.titleOxidative stress parameters in children with acute rheumatic feveren_US
dc.titleOxidative stress parameters in children with acute rheumatic fever
dc.typeArticleen_US

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