Polymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infection

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dc.contributor.authorEce, A
dc.contributor.authorTekes, S
dc.contributor.authorGürkan, F
dc.contributor.authorBilici, M
dc.contributor.authorBudak, T
dc.date.accessioned2024-04-24T17:11:32Z
dc.date.available2024-04-24T17:11:32Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The aim of this study was to investigate whether the angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (A1166C) gene polymorphisms were associated with the renal scar formation secondary to recurrent urinary tract infection in children without uropathy. Methods: The polymorphisms were investigated by polymerase chain reaction in 97 children (81 females, 16 males; age, 2.5-13 years) with recurrent urinary tract infection and 100 healthy controls as a single centre study. Children with vesicoureteral reflux, bladder dysfunction and other uropathies were excluded. The dimercaptosuccinic acid (DMSA) scan performed at least 3 months after a proven urinary tract infection and the result of the last DMSA was taken into consideration. Results: Renal scarring was found in 30 patients (30.9%) using DMSA scan. The number of urinary tract infection attacks was significantly higher in patients with renal scarring compared with children without scarring (P < 0.05). The follow-up period and male/female ratio of patients with or without renal scarring was similar (P > 0.05). Age at the first urinary tract infection was lower in the group with scarring. The ACE insertion/deletion genotype distribution and D allele frequency were similar between patients and controls (P > 0.05), and in patients with renal scarring and those without renal scarring. Also, the angiotensin II type 1 receptor gene polymorphism was not associated with renal parenchymal damage (P > 0.05). Conclusion: The results indicated that the ACE insertion/deletion and angiotensin II type 1 receptor gene polymorphisms were not independent risk factors for renal scar formation in recurrent urinary tract infection of paediatric patients without uropathy.en_US
dc.identifier.doi10.1111/j.1440-1797.2005.00430.x
dc.identifier.endpage381en_US
dc.identifier.issn1320-5358
dc.identifier.issue4en_US
dc.identifier.pmid16109085
dc.identifier.scopus2-s2.0-28444452173
dc.identifier.scopusqualityQ2
dc.identifier.startpage377en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1797.2005.00430.x
dc.identifier.urihttps://hdl.handle.net/11468/17590
dc.identifier.volume10en_US
dc.identifier.wosWOS:000231152100011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofNephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin Converting Enzyme Geneen_US
dc.subjectAngiotensin Ii Type 1 Receptor Geneen_US
dc.subjectPolymorphismen_US
dc.subjectRenal Scarringen_US
dc.subjectUrinary Tract Infectionen_US
dc.titlePolymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infectionen_US
dc.titlePolymorphisms of the angiotensin converting enzyme and angiotensin II type 1 receptor genes and renal scarring in non-uropathic children with recurrent urinary tract infection
dc.typeArticleen_US

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