Relationship between endothelial dysfunction and prosthetic heart valve thrombosis: a preliminary investigation

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dc.contributor.authorKaya, H.
dc.contributor.authorOzkan, M.
dc.contributor.authorYildiz, M.
dc.date.accessioned2024-04-24T17:37:55Z
dc.date.available2024-04-24T17:37:55Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: The etiopathogenesis of prosthetic heart valve thrombosis (PHVT) is multifactorial. Since the relationship between PHVT and endothelial function is never studied, we aimed to analyze the role of endothelial function in patients with PHVT. PATIENTS AND METHODS: Twenty-two patients with PHVT (14 female, 31.8% with atrial fibrillation, mean age 46.0 +/- 12.2) and 22 controls with prosthetic heart valves (17 female, 36.4% with atrial fibrillation, mean age 45.7 +/- 11.5) were prospectively evaluated. Two groups had similar demographic and echocardiographic characteristics. Endothelial function was evaluated in all patients by the non-invasive measurement of flow mediated dilatation (FMD) of brachial artery. High-resolution ultrasound was used to measure brachial artery diameter at rest, during reactive hyperemia (endothelium-dependent, FMD), and following sublingual administration of nitroglycerin (endothelium-independent, nitroglycerin-mediated vasodilatation, NMD). RESULTS: Functional capacity at presentation determined as mean NYHA functional capacity class was worse in patients with PHVT than in control group (2.1 +/- 0.6 vs. 1.3 +/- 0.6; p < 0.0001). FMD was significantly reduced in patients with PHVT compared with control group (4.01 +/- 1.52 vs. 8.48 +/- 3.37; p < 0.0001). NMD did not differ between two groups (11.77 +/- 2.30 vs. 13.38 +/- 3.50; p = 0.08). FMD level of < 5.65 predicted prosthetic valve thrombosis with an 82% sensitivity and 77% specificity (area under the curve = 0.888, p < 0.0001). CONCLUSIONS: This study demonstrated the endothelial dysfunction in patients with PHVT compared with well-matched control group. In this study, we found that patients with PHVT have endothelial dysfunction which might contribute to the development of thrombosis.en_US
dc.identifier.endpage1598en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid23832724
dc.identifier.scopus2-s2.0-84884343468
dc.identifier.scopusqualityQ2
dc.identifier.startpage1594en_US
dc.identifier.urihttps://hdl.handle.net/11468/21247
dc.identifier.volume17en_US
dc.identifier.wosWOS:000324924200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial Functionen_US
dc.subjectProsthetic Heart Valveen_US
dc.subjectThrombosisen_US
dc.titleRelationship between endothelial dysfunction and prosthetic heart valve thrombosis: a preliminary investigationen_US
dc.titleRelationship between endothelial dysfunction and prosthetic heart valve thrombosis: a preliminary investigation
dc.typeArticleen_US

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