Effects of in vivo freezing and mannitol in intestinal ischaemia-reperfusion injury

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dc.contributor.authorAldemir, M
dc.contributor.authorÖztürk, H
dc.contributor.authorGüloglu, C
dc.contributor.authorBüyükbayram, H
dc.date.accessioned2024-04-24T16:18:39Z
dc.date.available2024-04-24T16:18:39Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The main purpose of this study was to investigate whether in vivo freezing and mannitol administration can protect the small intestine against ischaemia-reperfusion (I-R) injury. Methods: Fifty male Sprague-Dawley rats (200-225 g) were divided into 5 groups each containing 10 rats; group SO, sham operation group; group 1, mesenteric ischaemia group; group R, ischaemia-reperfusion (I-R); group FR, I-R plus in vivo freezing; group MR, I-R plus mannitol treatment. Intestinal ischaemia for 30 min and reperfusion for 60 min were applied. Ileum specimens were obtained to determine the tissue levels of malondialdehyde (MDA) and histological changes. Results: The mucosal injury scores of group R were significantly higher than those of the group I (P < 0.0001). The mucosal injury scores in the groups FR and MR were significantly lower than the group R (P < 0.0001 and P < 0.0001, respectively). In the group FR, mucosal injury scores were not significantly different from those of group I (P = 0.123). However, mucosal injury scores of group MR were significantly less when compared to those of group I (P = 0.01). Mean MDA levels of group R were significantly higher than those of the group I (P < 0.0001). Mean MDA levels of groups FR and MR were significantly lower than those of group R (P < 0.0001 and P < 0.0001, respectively.). In addition, MDA levels of group FR were significantly higher than those of group MR (P < 0.0001). Conclusion: In conclusion, these observations suggest that the in vivo freezing of SMA and the pre-treatment with mannitol before reperfusion period may be useful in preventing intestinal reperfusion injury. (C) 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0020-1383(02)00351-0
dc.identifier.endpage179en_US
dc.identifier.issn0020-1383
dc.identifier.issue3en_US
dc.identifier.pmid12623246
dc.identifier.scopus2-s2.0-0037338161
dc.identifier.scopusqualityQ1
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1016/S0020-1383(02)00351-0
dc.identifier.urihttps://hdl.handle.net/11468/16216
dc.identifier.volume34en_US
dc.identifier.wosWOS:000181715000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal of The Care of The Injured
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of in vivo freezing and mannitol in intestinal ischaemia-reperfusion injuryen_US
dc.titleEffects of in vivo freezing and mannitol in intestinal ischaemia-reperfusion injury
dc.typeArticleen_US

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