Intraoperative intravenous ketamine in combination with epidural analgesia: Postoperative analgesia after renal surgery

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dc.contributor.authorKararmaz, A
dc.contributor.authorKaya, S
dc.contributor.authorKaraman, H
dc.contributor.authorTurhanoglu, S
dc.contributor.authorOzyilmaz, MA
dc.date.accessioned2024-04-24T17:15:01Z
dc.date.available2024-04-24T17:15:01Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe designed this double-blinded, randomized, controlled study to evaluate the effect of small-dose ketamine IV in combination with epidural morphine and bupivacaine on postoperative pain after renal surgery. An epidural catheter was inserted, and the administration of morphine and bupivacaine was started before surgery. Forty patients were assigned to one of two groups (ketamine or control). The ketamine group was administered a ketamine bolus and infusion during surgery. The median visual analog pain scale (VAS) scores at rest were significantly lower in the ketamine group during the first 6 h (P < 0.01). VAS pain scores on coughing were also significantly lower in the ketantine group (P < 0.01). Cumulative postoperative total analgesic consumption was less in the ketamine group on Days 1 and 2 (P < 0.001). The first analgesic demand time was shorter in the control group (9.2 +/- 11.5 min) than in the ketamine group (22.3 +/- 17.1 min) (P < .0001). The incidence of nausea and pruritus was more frequent in the control group (P < 0.05). In conclusion, postoperative analgesia was more effective when spinal cord and brain sensitization were blocked by a combination of epidural morphine/ bupivacaine and IV ketamine.en_US
dc.identifier.doi10.1213/01.ANE.0000080205.24285.36
dc.identifier.endpage1096en_US
dc.identifier.issn0003-2999
dc.identifier.issue4en_US
dc.identifier.pmid14500163
dc.identifier.scopus2-s2.0-0141458072
dc.identifier.scopusqualityQ1
dc.identifier.startpage1092en_US
dc.identifier.urihttps://doi.org/10.1213/01.ANE.0000080205.24285.36
dc.identifier.urihttps://hdl.handle.net/11468/18307
dc.identifier.volume97en_US
dc.identifier.wosWOS:000185492300030
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia and Analgesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleIntraoperative intravenous ketamine in combination with epidural analgesia: Postoperative analgesia after renal surgeryen_US
dc.titleIntraoperative intravenous ketamine in combination with epidural analgesia: Postoperative analgesia after renal surgery
dc.typeArticleen_US

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