Clinical and pathological features of patients with resected synovial sarcoma: A multicenter retrospective analysis of the Anatolian Society of Medical Oncology

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dc.contributor.authorTarkan, Yetisyigit
dc.contributor.authorErkan, Arpaci
dc.contributor.authorSelcuk, Erdogan Seber
dc.contributor.authorMehmet, Kucukoner
dc.contributor.authorTugba, Kos F.
dc.contributor.authorOzlem, Uysal Sonmez
dc.contributor.authorSuleyman, Alici
dc.date.accessioned2024-04-24T17:24:13Z
dc.date.available2024-04-24T17:24:13Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. Aims: We aimed to evaluate the factors affecting the outcomes of SS patients in the adjuvant setting. Patients and Methods: In this Turkish multicenter study, we assessed the data of 69 SS patients regarding prognostic factors for SS patients retrospectively. Results: Our study included 69 localized SS patients (38 males and 31 females) with a median age of 34.5 years (minimum-maximum: 14-68 years). Overall survival (OS) and disease free survival (DFS) rates for 5 years were 64% and 25%, respectively. All patients under went surgical treatment; 64 patients were treated with a wide excision and 5 patients had an amputation. According to the univariate analysis, adverse prognostic factors for OS were male sex, higher mitotic activity, high Ki-67 levels, trunk localization and inadequate surgical margins. In multivariate analysis, none of these factors had independent significant association with OS. Prognostic factors for DFS; in the univariate analysis were higher mitotic activity, high Ki-67 levels and inadequate surgical margins. Only higher mitotic activity (>= 10 high-power field) was significantly associated with worse DFS in the multivariate analysis (hazard ratio: 0.30, % confidence interval: 0.11-0.80, P = 0.017). Conclusion: Our study confirms that high mitotic activity is significantly associated with decreased DFS. The question of whether the chemotherapy provides a survival advantage in patients having adverse prognostic factors requires confirmation in randomized trials.en_US
dc.identifier.doi10.4103/0973-1482.131381
dc.identifier.endpage78en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue1en_US
dc.identifier.pmid24762490
dc.identifier.scopus2-s2.0-84899692683
dc.identifier.scopusqualityQ3
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.131381
dc.identifier.urihttps://hdl.handle.net/11468/19530
dc.identifier.volume10en_US
dc.identifier.wosWOS:000335372300015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKi-67en_US
dc.subjectMitotic Activityen_US
dc.subjectSynovial Sarcomaen_US
dc.titleClinical and pathological features of patients with resected synovial sarcoma: A multicenter retrospective analysis of the Anatolian Society of Medical Oncologyen_US
dc.titleClinical and pathological features of patients with resected synovial sarcoma: A multicenter retrospective analysis of the Anatolian Society of Medical Oncology
dc.typeArticleen_US

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