Comparative study of the quantitative resolution of paracetamol and methocarbamol mixture by spectrophotometry with wavelet transform and UPLC techniques

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dc.authorid0000-0002-9004-8993en_US
dc.authorid0000-0003-3092-8080en_US
dc.contributor.authorGüzel, Remziye
dc.contributor.authorErtekin, Zehra Ceren
dc.contributor.authorZiyadanoğulları, Berrin
dc.contributor.authorDinç, Erdal
dc.contributor.authorZiyadanoğulları, Recep
dc.date.accessioned2023-03-09T12:57:32Z
dc.date.available2023-03-09T12:57:32Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Ziya Gökalp Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümüen_US
dc.description.abstractThe aim of this study was to develop a new simple and cost-effective spectrophotometric method to be used as an alternative to chromatography for the analysis of paracetamol and methocarbamol (PAR-MET) combination. In this regard, a comparative study on the quantitative resolution of PAR and MET mixture using continuous wavelet transform (CWT) and ultra-performance liquid chromatography (UPLC) techniques was performed. In interpretation of the spectrophotometric data, three different wavelet families Biorthogonal3.5 (Bior3.5), Mexican Hat Function (Mexh), and Symlets5 (Sym5) were found suitable to get better transform of zero-order spectra of the samples containing PAR and MET. The concentrations of PAR and MET in the working range of 4.0 - 20.0 mu g/mL and 5.0 - 45.0 mu g/mL, respectively, were proportional to the wavelet amplitudes. This mathematical relationship was used to construct calibration curves for each compound. After validation of the CWT method, analyses of commercial tablets were successfully performed. A new UPLC method was developed and validated in order to compare the results with those obtained by the CWT method and the data were found comparable. The analysis of results obtained from experimental trials showed that the proposed CWTmethod is suitable for the quality control and quantitative assessment of both active substances in tablet formulations.en_US
dc.identifier.citationGüzel, R., Ertekin, Z.C., Ziyadanoğulları, B., Dinç, E. ve Ziyadanoğulları, R. (2022). Comparative study of the quantitative resolution of paracetamol and methocarbamol mixture by spectrophotometry with wavelet transform and UPLC techniques. Pharmaceutical Chemistry Journal, Pharmaceutical Chemistry Journal, 55(10), 1126-1132.en_US
dc.identifier.doi10.1007/s11094-021-02547-1
dc.identifier.endpage1132en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85124077848
dc.identifier.scopusqualityQ4
dc.identifier.startpage1126en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11094-021-02547-1
dc.identifier.urihttps://hdl.handle.net/11468/11347
dc.identifier.volume55en_US
dc.identifier.wosWOS:000749961000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGüzel, Remziye
dc.institutionauthorZiyadanoğulları, Berrin
dc.institutionauthorZiyadanoğulları, Recep
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpectrophotometryen_US
dc.subjectWavelet transformen_US
dc.subjectUltra-performance liquid chromatographyen_US
dc.subjectParacetamolen_US
dc.subjectMethocarbamolen_US
dc.titleComparative study of the quantitative resolution of paracetamol and methocarbamol mixture by spectrophotometry with wavelet transform and UPLC techniquesen_US
dc.titleComparative study of the quantitative resolution of paracetamol and methocarbamol mixture by spectrophotometry with wavelet transform and UPLC techniques
dc.typeArticleen_US

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