Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives

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dc.contributor.authorCulhaoglu, Burcu
dc.contributor.authorCapan, Asli
dc.contributor.authorBoga, Mehmet
dc.contributor.authorOzturk, Mehmet
dc.contributor.authorOzturk, Turan
dc.contributor.authorTopcu, Gulacti
dc.date.accessioned2024-04-24T17:18:35Z
dc.date.available2024-04-24T17:18:35Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Flavones, are a class of naturally occuring polyphenolic compounds which have 2-phenylchromen-4-one structure. Various studies showed that flavones have several pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antitumour and antiallergic. In the present study, 3-hydroxyflavones also called flavonols, posessing 4'-dialkylamino moiety were synthesized, and their antioxidant and anticholinesterase activities were investigated by comparison with unmodified 3-hydroxflavone. Method: For investigation of antioxidant potential, radical scavenging assays (DPPH., ABTS(+)-, O-2(-)) were used along with CUPRAC and lipid peroxidation inhibitory assays, as well as anticholinesterase activity by Ellman method. Results: The best results were obtained for 4'-N, N-dimethyl flavonol (1) in both antioxidant and anticholinesterase activity tests, possibly due to its least steric hinderance effect. It exhibited remarkable DPPH free radical scavenging activity (2.43 perpendicular to 0,09 mu g/mL) competing with a standard compound quercetin (2.10 +/- 0,10 mu g/mL). Moreover, the other tested flavonols also showed high antioxidant activities. Compounds 5 and 6 exhibited close IC50 values to those of compound 1. Conclusion: Antioxidant activity test results were found to be well correlated with anticholinesterase activity test results indicating possible role of antioxidant compounds in the treatment of Alzheimer's disease.en_US
dc.description.sponsorshipIstanbul Technical University, Department of Scientific Research Projectsen_US
dc.description.sponsorshipThe authors are thankful to Istanbul Technical University, Department of Scientific Research Projects, for financial support for this study which is a part of the PhDs thesis of Burcu Culhaoglu.en_US
dc.identifier.doi10.2174/1573406412666161104121642
dc.identifier.endpage259en_US
dc.identifier.issn1573-4064
dc.identifier.issn1875-6638
dc.identifier.issue3en_US
dc.identifier.pmid27823563
dc.identifier.scopus2-s2.0-85019767059
dc.identifier.scopusqualityQ3
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.2174/1573406412666161104121642
dc.identifier.urihttps://hdl.handle.net/11468/18835
dc.identifier.volume13en_US
dc.identifier.wosWOS:000402477800005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofMedicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectFlavonoiden_US
dc.subjectFlavonolen_US
dc.subject3-Hydroxyflavoneen_US
dc.titleAntioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivativesen_US
dc.titleAntioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives
dc.typeArticleen_US

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