Oxidative stress parameters and ceruloplasmin levels in patients with severe preeclampsia
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Editrice Univ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. Oxidative stress is believed to have a role in the development of preeclampsia (PE). It is known that an increased ceruloplasmin (CP) level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and CP levels in patients with severe PE. Patients and Methods. Sixty patients with severe PE and 60 healthy pregnant women were recruited to the study. All study subjects were divided into 2 groups; group 1(n=60) consisted of patients with severe PE, and group 2 (n=60) consisted of healthy pregnant subjects. Blood samples were obtained to measure CP, total antioxidant status and total oxidant status from all subjects. Oxidative stress index was calculated. Results. Compared to group 2; group 1 had significantly higher CP, total oxidant status, oxidative stress index and lower total antioxidant status levels (p<0.001, p<0.001, p=0.001, p=0.008, respectively). Serum CP levels were significantly correlated with oxidative stress index levels (r=0.385, p=0.002). Conclusion. The present study demonstrated that both oxidative stress and CP levels increased in patients with PE, and increased CP levels seem to be a consequence of oxidative stress.
Açıklama
Anahtar Kelimeler
Ceruloplasmin, Preeclampsia, Oxidative Stress Index, Total Antioxidant Status, Total Oxidant Status
Kaynak
Clinica Terapeutica
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
164
Sayı
2
