Novel markers of endothelial dysfunction and inflammation in Beh‡et's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

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dc.contributor.authorYuksel, Murat
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorOylumlu, Mustafa
dc.contributor.authorTurkcu, Fatih Mehmet
dc.contributor.authorBilik, Mehmet Zihni
dc.contributor.authorEkinci, Aysun
dc.contributor.authorElbey, Bilal
dc.date.accessioned2024-04-24T16:02:00Z
dc.date.available2024-04-24T16:02:00Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe etiology of Beh double dagger et's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Beh double dagger et's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Beh double dagger et's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum ADMA concentration and CIMT are independently associated with BD. Neutrophil counts, NLR, and serum ADMA level were higher, and lymphocyte count was lower in patients with active ocular BD compared to those of inactive ocular BD group. Carotid intima media thickness, serum ADMA level, EFT, and NLR were increased in ocular BD patients compared to healthy subjects. In addition, both serum ADMA level and NLR were associated with disease activity of ocular involvement. Increase in disease duration was associated with increase in CIMT and EFT which suggests that anatomical changes occur in time during the disease course. Increased CIMT, serum ADMA level, EFT, and NLR may provide new clues about the role of ED and inflammation in the etiopathogenesis of BD.en_US
dc.description.sponsorshipDicle University DUBAP departmenten_US
dc.description.sponsorshipThe authors would like to express their appreciation to Dicle University DUBAP department for their sponsorship during Elisa kit attainment.en_US
dc.identifier.doi10.1007/s10067-015-2907-0
dc.identifier.endpage708en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue3en_US
dc.identifier.pmid25744156
dc.identifier.scopus2-s2.0-84960353921
dc.identifier.scopusqualityQ1
dc.identifier.startpage701en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-015-2907-0
dc.identifier.urihttps://hdl.handle.net/11468/14564
dc.identifier.volume35en_US
dc.identifier.wosWOS:000372429000019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdmaen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectCarotid Intima Media Thicknessen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.subjectRheumatic Diseasesen_US
dc.titleNovel markers of endothelial dysfunction and inflammation in Beh‡et's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratioen_US
dc.titleNovel markers of endothelial dysfunction and inflammation in Beh‡et's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio
dc.typeArticleen_US

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