The effect of celecoxib, a selective COX-2 inhibitor, on liver ischemia/reperfusion-induced oxidative stress in rats

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dc.contributor.authorOzturk, H
dc.contributor.authorGezici, A
dc.contributor.authorOzturk, H
dc.date.accessioned2024-04-24T16:14:51Z
dc.date.available2024-04-24T16:14:51Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study examined the effects of celecoxib on hepatic ischemia/reperfusion (I/R) injury in rats. A total of 40 male Sprague-Dawley rats weighing 190-210g were randomized into 4 groups of 10: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats that underwent liver ischemia for 1 h followed by reperfusion for 45 min; (4) I-R/Celecoxib group: rats pretreated with celecoxib Q mg kg(-1), i.p.) 40 min before liver I/R. Tc-99m sulfur colloid images were used to measure the uptake ratio and perfusion index. Liver tissues were taken to determine SOD, CAT, GSH-Px, and MDA levels and for biochemical and histological evaluation. The plasma ALT, AST, GGT, and LDH activities were higher in group 3 than in group 4. The uptake ratio was significantly lower in group 3 compared to groups 1, 2, and 4. In addition, in group 4, the uptake ratio and perfusion index were also significantly higher compared to group 3. MDA values and the hepatic injury score decreased, while the SOD, CAT, and GSH-Px values increased in group 4 compared to group 3. In group 3, hepatocytes were swollen with marked vacuolization. Group 4 showed well preserved liver parenchyma with hepatocytes arranged radially around the central vein; there were regular sinusoidal structures with normal morphology without any signs of congestion. We showed that celecoxib has beneficial effects in hepatic I/R injury and may protect the liver. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.hepres.2005.11.003
dc.identifier.endpage83en_US
dc.identifier.issn1386-6346
dc.identifier.issn1872-034X
dc.identifier.issue2en_US
dc.identifier.pmid16384742
dc.identifier.scopus2-s2.0-31344476480
dc.identifier.scopusqualityQ1
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.1016/j.hepres.2005.11.003
dc.identifier.urihttps://hdl.handle.net/11468/15448
dc.identifier.volume34en_US
dc.identifier.wosWOS:000235502800003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHepatology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectLiveren_US
dc.subjectCoxen_US
dc.subjectCelecoxiben_US
dc.subjectLipid Peroxidationen_US
dc.titleThe effect of celecoxib, a selective COX-2 inhibitor, on liver ischemia/reperfusion-induced oxidative stress in ratsen_US
dc.titleThe effect of celecoxib, a selective COX-2 inhibitor, on liver ischemia/reperfusion-induced oxidative stress in rats
dc.typeArticleen_US

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