Extremely low frequency magnetic fields cause oxidative DNA damage in rats

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dc.contributor.authorYokus, Beran
dc.contributor.authorAkdag, M. Zulkuf
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorKizil, Murat
dc.date.accessioned2024-04-24T16:24:45Z
dc.date.available2024-04-24T16:24:45Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To detect the genotoxic effects of extremely low frequency (ELF) -magnetic fields (MF) on oxidative DNA base modifications [8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde)] in rat leucocytes, measured following exposure to ELF-MF. Materials and methods: After exposure to ELF-MF (50Hz, 100 and 500 mu T, for 2 hours/day during 10 months), DNA was extracted, and measurement of DNA lesions was achieved by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Results: Levels of FapyAde, FapyGua and 8OHdG in DNA were increased by both 100 mu T and 500 mu T ELF-MF as compared to a cage-control and a sham group; however, statistical significance was observed only in the group exposed to 100 mu T. Conclusion: This is the first study to report that ELF-MF exposure generates oxidatively induced DNA base modifications which are mutagenic in mammalian cells, such as FapyGua, FapyAde and 8-OH-Gua, invivo. This may explain previous studies showing DNA damage and genomic instability. These findings support the hypothesis that chronic exposure to 50-Hz MF may be potentially genotoxic. However, the intensity of ELF-MF has an important influence on the extent of DNA damage.en_US
dc.identifier.doi10.1080/09553000802348203
dc.identifier.endpage795en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue10en_US
dc.identifier.pmid18979312
dc.identifier.scopus2-s2.0-55349145975
dc.identifier.scopusqualityQ2
dc.identifier.startpage789en_US
dc.identifier.urihttps://doi.org/10.1080/09553000802348203
dc.identifier.urihttps://hdl.handle.net/11468/16838
dc.identifier.volume84en_US
dc.identifier.wosWOS:000260573400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDna Damageen_US
dc.subjectExtremely Low Frequency Magnetic Fielden_US
dc.subject8-Hydroxy-2'-Deoxyguanosineen_US
dc.subject8-Hydroxyguanineen_US
dc.subject2en_US
dc.subject6-Diamino-4-Hydroxy-5-Formamidopyrimidineen_US
dc.subject4en_US
dc.subject6-Diamino-5-Formamidopyrimidineen_US
dc.titleExtremely low frequency magnetic fields cause oxidative DNA damage in ratsen_US
dc.titleExtremely low frequency magnetic fields cause oxidative DNA damage in rats
dc.typeArticleen_US

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