Nitric oxide regulates expression of sonic hedgehog and hypoxia-inducible factor-1? in an experimental model of kidney ischemia-reperfusion

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorOzturk, Hulya
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T16:24:38Z
dc.date.available2024-04-24T16:24:38Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was designed to determine the effect of L-arginine on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of ischemia/reperfusion (I/R) injury. Unilaterally nephrectomized Sprague-Dawley rats were subjected to 60 minutes of left renal ischeMia followed by 45 minutes of reperfusion. Group I were sham-operated animals; group 2, I-R/Untreated animals; and group 3, I-R/L-Arg-treated animals. Serum creatinine, blood urea nitrogen (BUN), and kidney malondialdehyde (MDA eve were determined as well as examining the kidneys histologicall The treatment of rats with L-Arg produced a significant reduction in the levels of BUN, creatinine, MDA, and histopathological score compared to renal I/R groups. The Shh expression in the tubulus epithelia were intensely increased in the I-R/L-Arg group when compared to that of the Sham-control and the I-R/ untreated groups. Additionally, the HIF-fix expression in the tubulus epithelia and the interstitial spaces were intensely increased in the I-R/L-Arg group. These findings suggest that NO reduces the renal dysfunction associated with I/R of the kidney and may act as a trigger to induce Shh and HIF-1 activity.en_US
dc.identifier.doi10.1080/08860220601166289
dc.identifier.endpage256en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue3en_US
dc.identifier.pmid17497436en_US
dc.identifier.scopus2-s2.0-34248512606en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1080/08860220601166289
dc.identifier.urihttps://hdl.handle.net/11468/16798
dc.identifier.volume29en_US
dc.identifier.wosWOS:000246884800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal/Kidneyen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectHypoxia Inducible Factor Alpha (Hif-1a)en_US
dc.subjectSonic Hedgehog (Shh)en_US
dc.titleNitric oxide regulates expression of sonic hedgehog and hypoxia-inducible factor-1? in an experimental model of kidney ischemia-reperfusionen_US
dc.typeArticleen_US

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