Serum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary results

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dc.contributor.authorDal, M. S.
dc.contributor.authorKarakus, A.
dc.contributor.authorAydin, B. B.
dc.contributor.authorEkmen, M. O.
dc.contributor.authorUlas, T.
dc.contributor.authorAyyildiz, O.
dc.date.accessioned2024-04-24T17:38:03Z
dc.date.available2024-04-24T17:38:03Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The purpose of this study was to evaluate the uric acid (UA) and Creactive protein (CRP) levels in patients with immune thrombocytopenic purpura (ITP). PATIENTS AND METHODS: Forty patients with newly diagnosed ITP and 40 healthy individuals were enrolled in the study. The patients were divided into two groups; group 1 (n = 40) consisted of patients with ITP, and group 2 (n = 40) consisted of healthy subjects. UA and CRP levels were measured in the blood samples from them. RESULTS: There were no statistical differences in gender, age and body mass index between two groups (p > 0.05 for all). Compared to group 2, group 1 had significantly higher UA levels (p = 0.002), whereas CRP levels were not significantly different (p > 0.05). In ITP patients, serum UA and CRP levels significantly correlated with low platelet count (r = -0.362, p = 0.022; r = -0.383, p = 0.015, respectively); and UA levels significantly correlated with CRP levels (r = 0.436, p = 0.005). CONCLUSIONS: The present study showed that UA levels increased in patients with ITP and negatively correlated with platelet counts. UA levels might be a mediator of inflammation via enhanced production of inflammatory cytokines; they might also be a potential mediator of low platelet count, and could play a pathophysiological role in the development of ITP.en_US
dc.identifier.endpage4389en_US
dc.identifier.issn1128-3602
dc.identifier.issue22en_US
dc.identifier.pmid26636527
dc.identifier.scopus2-s2.0-84957958701
dc.identifier.scopusqualityQ2
dc.identifier.startpage4385en_US
dc.identifier.urihttps://hdl.handle.net/11468/21307
dc.identifier.volume19en_US
dc.identifier.wosWOS:000366757400026
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectImmune Thrombocytopenic Purpuraen_US
dc.subjectUric Aciden_US
dc.titleSerum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary resultsen_US
dc.titleSerum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary results
dc.typeArticleen_US

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