Paraoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndrome

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dc.contributor.authorEce, A
dc.contributor.authorAtamer, Y
dc.contributor.authorGürkan, F
dc.contributor.authorDavutoglu, M
dc.contributor.authorKoçyigit, Y
dc.contributor.authorTutanç, M
dc.date.accessioned2024-04-24T16:01:54Z
dc.date.available2024-04-24T16:01:54Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractReactive oxygen species (ROS) are reported to play a role in inducing the proteinuria of nephrotic syndrome (NS). This study investigated paraoxonase (PON), total antioxidant response (TAR), and oxidant total peroxide together with serum proteins and lipoproteins in children with steroid-sensitive NS. The study included 40 children with steroid-sensitive NS (21 with acute-period NS in group I, 19 nonproteinuric while receiving steroids in group II) and 22 sex- and age-matched formerly nephrotic children in remission weaned from steroids (group III). The following parameters were determined: total peroxide, oxidative stress index (OSI), PON and TAR. Serum proteins and lipoproteins were also determined. Patients in the active phase of NS had significantly lower PON and TAR levels and higher OSI and total peroxide values than those in full remission; no differences were found in PON, TAR, or OSI values of groups I and II. Significant correlations were found between PON, TAR, and total peroxide. Serum total protein had a significantly positive correlation with PON and negative correlation with total peroxide in acute-period NS patients. Our results demonstrate greater oxidative stress and decreased antioxidants in the active phase of steroid-sensitive NS and while patients receive steroids than during full remission. Low-dose alternate-day steroids do not seem to decrease oxidative stress even while proteinuria ceases. Despite some conflicting data increased oxidation and/or decreased antioxidant response may be related to the pathogenesis of steroid-sensitive NS.en_US
dc.identifier.doi10.1007/s00467-005-1956-z
dc.identifier.endpage1284en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue9en_US
dc.identifier.pmid15942780
dc.identifier.scopus2-s2.0-24044491583
dc.identifier.scopusqualityQ1
dc.identifier.startpage1279en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-005-1956-z
dc.identifier.urihttps://hdl.handle.net/11468/14482
dc.identifier.volume20en_US
dc.identifier.wosWOS:000231217600014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectNephrotic Syndromeen_US
dc.subjectOxidant Stressen_US
dc.subjectParaoxonaseen_US
dc.subjectProteinsen_US
dc.titleParaoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndromeen_US
dc.titleParaoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndrome
dc.typeArticleen_US

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