Fibroblast growth factor-1 expression in the endometrium of patients with repeated implantation failure after in vitro fertilization

Basit Öğe Kaydı
dc.contributor.authorSak, M. E.
dc.contributor.authorGul, T.
dc.contributor.authorEvsen, M. S.
dc.contributor.authorSoydinc, H. E.
dc.contributor.authorSak, S.
dc.contributor.authorOzler, A.
dc.contributor.authorAlabalik, U.
dc.date.accessioned2024-04-24T17:34:01Z
dc.date.available2024-04-24T17:34:01Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: An examination of the alterations in Fibroblast Growth Factor-1 (FGF-1) expression in a group of repeated implantation failure after in vitro fertilization (IVF) patients, when compared to fertile patients. PATIENTS AND METHODS: Study group consisted of 24 patients with repeated implantation failure and 29 fertile control patients. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for the fibroblast growth factor-1 (FGF-1) with antibodies. RESULTS: In the study group all patients have primary infertility (n = 24), and the average duration of infertility was 3.9 +/- 1.3 years. The average recurrent IVF failure was 2.6 +/- 0.6 attemps. There were no significant differences in the histological data according to the Noyes classification (p = 0.226) and age (p = 0.231) between the patients in the study and control groups (n=29). The control group was found to have more severe expression of FGF-1 (< 0.001) than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. CONCLUSIONS: Endometrial glandular epithelial cells, stromal cells and vascular endothelial cells of the control and study group were evaluated and it was found that the control group displayed a stronger expression of the FGF-1 (< 0.001). The expression of FGF-1 in the IVF implantation failure group is less than in the fertile group, which suggests that growth factors such as FGF-1 are important maternal factors effecting implantation.en_US
dc.identifier.endpage402en_US
dc.identifier.issn1128-3602
dc.identifier.issue3en_US
dc.identifier.pmid23426545
dc.identifier.scopus2-s2.0-84878532741
dc.identifier.scopusqualityQ2
dc.identifier.startpage398en_US
dc.identifier.urihttps://hdl.handle.net/11468/20922
dc.identifier.volume17en_US
dc.identifier.wosWOS:000319225200016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImplantation Failureen_US
dc.subjectIvfen_US
dc.subjectFgf-1en_US
dc.titleFibroblast growth factor-1 expression in the endometrium of patients with repeated implantation failure after in vitro fertilizationen_US
dc.titleFibroblast growth factor-1 expression in the endometrium of patients with repeated implantation failure after in vitro fertilization
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu