HLA DQB1 alleles are related with nonalcoholic fatty liver disease

Basit Öğe Kaydı
dc.contributor.authorDoganay, Levent
dc.contributor.authorKatrinli, Seyma
dc.contributor.authorColak, Yasar
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorZemheri, Ebru
dc.contributor.authorOzturk, Oguzhan
dc.contributor.authorEnc, Feruze Yilmaz
dc.date.accessioned2024-04-24T16:02:17Z
dc.date.available2024-04-24T16:02:17Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD is a complex disease and inflammation is a crucial component in the disease pathogenesis. Recent genome wide association studies in hepatology area highlighted significant relations with human leukocyte antigen (HLA) DQ region and certain liver diseases. The previous animal models also emphasized the involvement of adaptive immune system in the liver damage pathways. To investigate possible polymorphisms in the HLA region that can contribute to the immune response affecting the NAFLD, we enrolled 93 consecutive biopsy proven NAFLD patients and a control group consisted of 101 healthy people and genotyped HLA DQB1 alleles at high resolution by sequence specific primers-polymerase chain reaction. The mean NAFLD activity score (NAS) was 5.2 +/- 1.2, fibrosis score was 0.9 +/- 0.9, ALT was 77 +/- 47.4 U/L, AST was 49.4 26.3 U/L. Among 13 HLA DQB1 alleles analyzed in this study, DQB1*06:04 was observed significantly at a more frequent rate among the NAFLD patients compared to that of healthy controls (12.9 vs. 2 % chi(2) = 8.6, P = 0.003, P-c = 0.039, OR: 7.3 95 % CI 1.6-33.7). In addition, the frequency of DQB1*03:02 was significantly higher in the healthy control group than the NAFLD patients (24.8 vs. 7.5 %, chi(2) = 10.4, P = 0.001, P-c = 0.013, OR: 0.2, 95 % CI 0.1-0.6). NAFLD patients were grouped according to their fibrosis score and NAS. The distribution of DQB1 alleles over stratified NAFLD patients did not reveal any statistically significant relation. Taken together, immune repertoire of individuals may have an effect on NAFLD pathogenesis and therefore, in NA-FLD, adaptive immunity pathways should be investigated.en_US
dc.description.sponsorshipIstanbul Technical Universityen_US
dc.description.sponsorshipThis study is supported by internal research funds of Istanbul Technical University.en_US
dc.identifier.doi10.1007/s11033-014-3688-2
dc.identifier.endpage7943en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue12en_US
dc.identifier.pmid25156535
dc.identifier.scopus2-s2.0-84926623695
dc.identifier.scopusqualityQ2
dc.identifier.startpage7937en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-014-3688-2
dc.identifier.urihttps://hdl.handle.net/11468/14730
dc.identifier.volume41en_US
dc.identifier.wosWOS:000349005800024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNonalcoholic Fatty Liver Disease (Nafld)en_US
dc.subjectNonalcoholic Steatohepatitis (Nash)en_US
dc.subjectHla Dqen_US
dc.subjectLiveren_US
dc.subjectInflammationen_US
dc.titleHLA DQB1 alleles are related with nonalcoholic fatty liver diseaseen_US
dc.titleHLA DQB1 alleles are related with nonalcoholic fatty liver disease
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu