Chemical and Biological Perspectives of Monoterpene Indole Alkaloids From Rauwolfia species
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The biosynthesis of monoterpene indole alkaloids (MIAs) starts with a geraniol
for the terpenoid portion. Secologanin, a secoiridoid glycoside, is derived from
10-hydroxygeraniol, produced in the presence of geraniol 10-hydroxylase. The
indole portion of MIAs contain tryptamine, produced by the decarboxylation of
tryptophan. Conjugation of secologanin with tryptamine is achieved with strictosidine
synthase to produce strictosidine. Over 2500 known MIAs found in
many plants from several families, such as Apocynaceae, Loganiaceae, Rubiaceae,
and Nyssaceae, are produced by modification of strictosidine. A number
of pharmacologically active compounds, namely, reserpine, ajmalicine, ajmaline,
serpentine, and yohimbine, isolated from different Rauwolfia species, are
examples of MIAs
Açıklama
Anahtar Kelimeler
Monoterpene Indole Alkaloids From Rauwolfia species
Kaynak
Studies in Natural Products Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
61
Sayı
Künye
Boğa, M., Bingül, M., Özkan, E.E. ve Şahin, H. (2018). Chemical and Biological Perspectives of Monoterpene Indole Alkaloids From Rauwolfia species. A. Rahman (Ed.). Studies in Natural Products Chemistry içinde. (pp. 251-299). Cambridge: Elsevier.
