Dynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3T MR scanner

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dc.contributor.authorSenturk, Senem
dc.contributor.authorOguz, Kader Karli
dc.contributor.authorCila, Aysenur
dc.date.accessioned2024-04-24T17:33:31Z
dc.date.available2024-04-24T17:33:31Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractPURPOSE To determine whether there are statistically significant differences in cerebral blood volume (CBV) and cerebral blood flow (CBF) of brain tumors of different histopathologic types including primary and secondary benign and malignant lesions. To determine whether these measurements relate to tumor grade. MATERIALS AND METHODS Forty-five patients with brain tumors, age 2 to 79 years, underwent dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion magnetic resonance imaging (MRI) using a 3T MR scanner. The lesions were evaluated by measurements of relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF). The Mann-Whitney U test was used to compare rCBV and rCBF measurements of tumor groups-13 low-grade and 13 high-grade neuroepithelial (NE) tumors, five metastases, 10 meningiomas, and four others. Peritumoral rCBV and rCBF measurements of high grade NE tumors and metastases were also compared. The relationship between rCBV and rCBF measurements was evaluated by Spearman rank correlation. RESULTS Measurements of rCBV and rCBF were statistically significantly higher (P < 0.05) in high-grade NE tumors than in low-grade NE tumors. The difference was not statistically significant in comparing high-grade NE tumors with metastases and meningiomas. Peritumoral rCBV of high-grade NE tumors was significantly higher than peritumoral rCBV of metastases (P < 0.05). There was a strong correlation between rCBV and rCBF values. CONCLUSION CBV and CBF measurements provided by 3T perfusion MRI can help to predict NE tumor graying preoperatively, and differentiate between primary brain tumors and metastases.en_US
dc.identifier.endpage12en_US
dc.identifier.issn1305-3825
dc.identifier.issue1en_US
dc.identifier.pmid19263367
dc.identifier.scopus2-s2.0-66149156948
dc.identifier.scopusqualityQ2
dc.identifier.startpage3en_US
dc.identifier.urihttps://hdl.handle.net/11468/20727
dc.identifier.volume15en_US
dc.identifier.wosWOS:000263847200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Soc Radiologyen_US
dc.relation.ispartofDiagnostic and Interventional Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain Neoplasmsen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subject3 Teslaen_US
dc.subjectPerfusion Weighted Imagingen_US
dc.titleDynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3T MR scanneren_US
dc.titleDynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3T MR scanner
dc.typeArticleen_US

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