Multiple primary malignant neoplasms: Multi-center results from Turkey

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dc.contributor.authorBabacan, N. A.
dc.contributor.authorAksoy, S.
dc.contributor.authorCetin, B.
dc.contributor.authorOzdemir, N. Y.
dc.contributor.authorBenekli, M.
dc.contributor.authorUyeturk, U.
dc.contributor.authorKaplan, M. Ali
dc.date.accessioned2024-04-24T17:37:40Z
dc.date.available2024-04-24T17:37:40Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Multiple primary malignant neoplasms (MPMNs) are defined as a diagnosis of two or more independent primary malignancies of different histologies/origins in an individual. The frequency of MPMN is being increasing. In this study we aimed to determine the frequency and clinical features of second primary cancers (SPCs). Methods: From January 1990 to December 2010, patients with MPMNs were screened in 5 centers. Data were obtained retrospectively from hospital charts. Results: Three hundred seventy-seven patients with MPMNs were evaluated. The median age at initial cancer diagnosis was 61 years (range 18-88). The median age at second cancer was 64 years (range 20-89). The median time between two cancer diagnoses was 15 months (range 0-504). Male to female ratio was 1.44 (M/F 223/154). The most frequent initial cancer types were head and neck (54 patients, 14.3%), breast (54 patients, 14.3%), and colorectal (43 patients, 11.4%). The most frequent second cancer types were lung (76 patients, 20.2%), colorectal (39 patients, 10.3%) and breast (33 patients, 8.8%). The most common cancer pairs in females were breast-gynecologic cancers (15 patients, 9.7%), colorectal-breast cancers (9 patients, 5.8%) and breast-colorectal cancers (7 patients, 4.5%). The most common cancer pairs in males were head and neck-lung cancers (29 patients, 13%), bladder-lung cancers (9 patients, 4%), and bladder-prostate cancers (7 patients, 3%). The median follow up was 36 months (range 1-595). Conclusion: Physicians should be aware of SPCs probabilities. Newly developed suspicious lesions should be evaluated rigorously. Histopathologic evaluations of suspicious lesions for second tumors should be used extensively if needed. In our series, the most common pairs were breast-gynecologic cancers in females and head and neck-lung cancers in males.en_US
dc.identifier.endpage775en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.pmid23335539en_US
dc.identifier.scopus2-s2.0-84872444158en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage770en_US
dc.identifier.urihttps://hdl.handle.net/11468/21109
dc.identifier.volume17en_US
dc.identifier.wosWOS:000313394000024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectChemotherapyen_US
dc.subjectMultiple Primary Malignanciesen_US
dc.subjectSecond Primaryen_US
dc.titleMultiple primary malignant neoplasms: Multi-center results from Turkeyen_US
dc.typeArticleen_US

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