Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases

Basit Öğe Kaydı
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorAkocak, Süleyman
dc.contributor.authorLolak, Nabih
dc.contributor.authorTuneğ, Muhammed
dc.contributor.authorBoǧa, Mehmet
dc.date.accessioned2021-10-01T11:49:57Z
dc.date.available2021-10-01T11:49:57Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this work, a series of histamine Schiff bases H(1-20) were assayed for antioxidant properties by using different bioanalytical methods such as DPPH-free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of them showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with percent inhibition of 97.03 and 93.64, respectively.en_US
dc.identifier.citationAkocak, S., Lolak, N., Tuneğ, M. ve Boǧa, M. (2019). Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases. Journal of the Turkish Chemical Society, Section A: Chemistry, 6(2), 157-164.en_US
dc.identifier.doi10.18596/jotcsa.521291
dc.identifier.endpage164en_US
dc.identifier.issn2149-0120
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85070509539
dc.identifier.scopusqualityQ3
dc.identifier.startpage157en_US
dc.identifier.trdizinid396154
dc.identifier.urihttps://dergipark.org.tr/en/pub/jotcsa/issue/43285/521291
dc.identifier.urihttps://hdl.handle.net/11468/7857
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/396154
dc.identifier.volume6en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorTuneğ, Muhammed
dc.institutionauthorBoǧa, Mehmet
dc.language.isoenen_US
dc.publisherTurkish Chemical Societyen_US
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectHistamineen_US
dc.subjectSchiff baseen_US
dc.titleAntioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff basesen_US
dc.titleAntioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases
dc.typeArticleen_US

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