Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Chemical Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this work, a series of histamine Schiff bases H(1-20) were assayed for antioxidant properties by using different bioanalytical methods such as DPPH-free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of them showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with percent inhibition of 97.03 and 93.64, respectively.
Açıklama
Anahtar Kelimeler
Alzheimer’s disease, Anticholinesterase, Antioxidant, Histamine, Schiff base
Kaynak
Journal of the Turkish Chemical Society, Section A: Chemistry
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
6
Sayı
2
Künye
Akocak, S., Lolak, N., Tuneğ, M. ve Boǧa, M. (2019). Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine schiff bases. Journal of the Turkish Chemical Society, Section A: Chemistry, 6(2), 157-164.
