Effect of lisinopril on oxidative stress in brain tissues of rats with L-Name induced hypertension

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dc.contributor.authorKirbas, Serkan
dc.contributor.authorKutluhan, Suleyman
dc.contributor.authorKirbas, Aynur
dc.contributor.authorSutcu, Recep
dc.contributor.authorKocak, Ahmet
dc.contributor.authorUzar, Ertugrul
dc.date.accessioned2024-04-24T17:27:43Z
dc.date.available2024-04-24T17:27:43Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Arterial hypertension is often associated with pathologies related with oxidative stress. Angiotensin converting enzyme (ACE) inhibitors have been used as a safe and effective treatment of hypertension and coronary heart disease. However, the significance of ACE inhibitor usage in hypertension-induced cerebrovascular and neurodegenerative diseases is still unknown. In this study, we aimed to investigate the effects of lisinopril, an ACE inhibitor, on oxidative stress and antioxidant enzyme activities in brain tissues of rats with L-NAME (N-omega-Nitro-L-Arginine Methyl Ester hydrochloride) induced hypertension. Methods: Thirty-two Sprague-Dawley rats were divided into four groups: Control, L-NAME, L-NAME plus lisinopril, and only lisinopril. Hypertension was induced by oral administration of the L-NAME (75 mg/kg/day) in drinking water for 6 weeks. Rats were treated with Lisinopril (10 mg/kg/day) for six weeks. Systolic blood pressures were measured at the first, third and sixth weeks by using tail cuff method. Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activity were measured from the brain tissue. Nitric oxide (NO) levels were measured from plasma. Results: Our results showed that L-NAME leads to an increase in systolic blood pressure of animals. The antihypertensive effect of lisinopril was observed. MDA level was significantly increased, and antioxidant enzymes activities were decreased in L-NAME given group (p<0.05). However, there was no statistically significant differences between the lisinopril given and other groups according to antioxidant enzymes activities (p>0.05). Conclusion: In our study, hypertension led to oxidative damage in brain tissues. Although lisinopril prevents the hypertension induced oxidative damage, direct antioxidant effect was not observed. Further studies are needed in order to gain certainty effect of lisinopril in brain tissue.en_US
dc.description.sponsorshipResearch Foundation of Suleyman Demirel University [0992-TU-05]en_US
dc.description.sponsorshipThis research was part of a project that was financially supported by the Research Foundation of Suleyman Demirel University (0992-TU-05). We thank them for this support.en_US
dc.identifier.doi10.5505/tjb.2013.83803
dc.identifier.endpage168en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84880111502
dc.identifier.scopusqualityQ3
dc.identifier.startpage163en_US
dc.identifier.trdizinid258730
dc.identifier.urihttps://doi.org/10.5505/tjb.2013.83803
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/258730
dc.identifier.urihttps://hdl.handle.net/11468/20161
dc.identifier.volume38en_US
dc.identifier.wosWOS:000323181600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-Name (N-Omega-Nitro-L-Arginine Methyl Ester Hydrochloride)en_US
dc.subjectHypertensionen_US
dc.subjectLisinoprilen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidant Enzymesen_US
dc.titleEffect of lisinopril on oxidative stress in brain tissues of rats with L-Name induced hypertensionen_US
dc.titleEffect of lisinopril on oxidative stress in brain tissues of rats with L-Name induced hypertension
dc.typeArticleen_US

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