The Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment

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dc.authorid0000-0002-8325-8116en_US
dc.authorid0000-0001-5784-7091en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorÖzkan, Esra Eroğlu
dc.contributor.authorErsoy, Ezgi
dc.contributor.authorCantürk, Yeter Yeşil
dc.contributor.authorKara, Emel Mataracı
dc.contributor.authorÇınar, Ercan
dc.contributor.authorŞahin, Hasan
dc.contributor.authorKarahan, Selim
dc.contributor.authorSancaktepe, Kübra Karaca
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorBoğa, Mehmet
dc.date.accessioned2024-02-22T13:11:20Z
dc.date.available2024-02-22T13:11:20Z
dc.date.issued09.06.2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.description.abstractThyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the gastrointestinal system, to its unique skin-related activities, the investigation of the medicinal properties of thyme has always been an alluring topic for researchers aiming to develop conventional medications from this traditional herb. With an incentive to contribute to the extensive thyme research, three Thymus L. species namely Thymus cariensis Hub-Mor. & Jalas (endemic), Thymus praceox subsp. grossheimii (Ronniger) Jalas, and Thymus pubescens Boiss. et Kotschy ex Celak from Turkey were deeply investigated within this study. The analysis of the phytochemical constituents of the extracts was conducted by LC-MS/MS. 12 biologically important secondary metabolites (p-coumaric acid, caffeic acid, salicylic acid, quinic acid, fumaric acid, vanillin, malic acid, rutin, apigenin, naringenin, and nicotiflorin) were detected in all extracts. Their total phenolic and flavonoid contents were calculated (11.15 ± 0.17—61.12 ± 2.59 μg PEs/mg extract, 2.53 ± 0.04—40.28 ± 0.92 μg QEs/mg extract, respectively), and the antioxidant potential of the extracts was evaluated by DPPH and ABTS radical scavenging and CUPRAC activity methods, accordingly, the extracts were shown to possess significant antioxidant activity. Among them, Thymus cariensis Hub-Mor. & Jalas was the most active with IC50 values of 34.97 ± 1.00 μg/ml and 9.98 ± 0.04 μg/ml regarding the DPPH and ABTS radical scavenging assays, respectively, and an A0.5 value of 5.80 ± 0.02 μg/ml according to CUPRAC activity method. Their anticholinesterase, antityrosinase, and antiurease activities were also tested, Thymus cariensis Hub-Mor. & Jalas (35.61 ± 1.20%) and Thymus pubescens Boiss. et Kotschy ex Celak aerial part extract (33.49 ± 1.39%) exhibited moderate antibutyrylcholinesterase activity at 200 μg/ml concentration. The results of the cell viability assay indicated that the extracts demonstrated moderate-to-low cytotoxicity on A498 human renal cell lines. Furthermore, all studied extracts exerted noteworthy antimicrobial activity, especially against Candida tropicalis (MIC values: 19.53—78.12 μg/ml). The presented data substantiates the use of thyme extracts as therapeutic agents in both ethnomedicine and conventional therapies.en_US
dc.identifier.citationÖzkan, E.E., Ersoy, E., Cantürk, Y.Y., Kara, E.M., Çınar, E., Şahin, H. ve diğerleri. (2022). The Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment. Frontiers in Pharmacology, 13, 923063en_US
dc.identifier.doi10.3389/fphar.2022.923063
dc.identifier.endpage13en_US
dc.identifier.issn1663-9812
dc.identifier.pmid35754476
dc.identifier.scopus2-s2.0-85133413376
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.923063/full
dc.identifier.urihttps://hdl.handle.net/11468/13370
dc.identifier.volume13en_US
dc.identifier.wosWOS:000815005700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Hasan
dc.institutionauthorKarahan, Selim
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers in Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymeen_US
dc.subjectThymus sp.en_US
dc.subjectAnatolian, LC-MS/MSen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-cholinesterase activityen_US
dc.subjectCytotoxicityen_US
dc.subjectCandida tropicalisen_US
dc.titleThe Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessmenten_US
dc.titleThe Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment
dc.typeArticleen_US

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