Is Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?

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dc.contributor.authorInal, Ali
dc.contributor.authorKaplan, M. Ali
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorKarakus, Abdullah
dc.contributor.authorNas, Necip
dc.contributor.authorGuven, Mehmet
dc.date.accessioned2024-04-24T17:28:15Z
dc.date.available2024-04-24T17:28:15Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Previous studies have pointed to many different prognostic factors for small cell lung cancer (SCLC) but diabetes mellitus (DM) has not been clearly or consistently identified as of prognostic value. The aim of this study was to investigate the prognostic significance of the characteristics of patients and clinical laboratory tests in SCLC. Specifically, we investigated that the impact of DM for survival in the patients receiving first-line etoposide plus cisplatin (EP) chemotherapy. Methods: We retrospectively reviewed 161 patients with SCLC with a focus on DM and other potential prognostic variables were chosen for univariate and multivariate analyses with respect to survival. Result: Among the sixteen variables of univariate analysis, five were identified to have prognostic significance: performance status (PS) (p < 0.001), stage (p=0.001), DM (p=0.005), serum albumin (p < 0.001) and hemoglobin levels (p=0.03). Multivariate analysis showed PS, stage and serum albumin level to be independent prognostic factors for survival (p=0.02, p=0.02 and p=0.009 respectively), but DM was not an independnet factor. Conclusion: In conclusion, PS, stage and serum albumin level were identified as important prognostic factors, while DM at the time of diagnosis of SCLC did not have prognostic importance for survival.en_US
dc.identifier.doi10.7314/APJCP.2012.13.4.1491
dc.identifier.endpage1494en_US
dc.identifier.issn1513-7368
dc.identifier.issue4en_US
dc.identifier.pmid22799354
dc.identifier.scopus2-s2.0-84873049064
dc.identifier.scopusqualityQ3
dc.identifier.startpage1491en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2012.13.4.1491
dc.identifier.urihttps://hdl.handle.net/11468/20378
dc.identifier.volume13en_US
dc.identifier.wosWOS:000306945700068
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSmall Cell Lung Canceren_US
dc.subjectPrognostic Factorsen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectSerum Factorsen_US
dc.titleIs Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?en_US
dc.titleIs Diabetes Mellitus a Prognostic Factor for Survival in Patients with Small Cell Lung Cancer?
dc.typeArticleen_US

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