The protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrin

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dc.contributor.authorKan, Yeter
dc.contributor.authorCengiz, Elif Ipek
dc.contributor.authorUgurlu, Pelin
dc.contributor.authorYanar, Mahmut
dc.date.accessioned2024-04-24T16:11:26Z
dc.date.available2024-04-24T16:11:26Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractDeltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnormalities using micronucleus test in Oreochromis niloticus, and the possible protective effect of vitamin E against deltamethrin inducing adverse effects in O. niloticus were investigated. Fish was fed with no pesticide + control diet, no pesticide + vitamin E-supplemented diet, 1.45 mu g/l deltamethrin + control diet, 1.45 mu g/l deltamethrin + vitamin E-supplemented diet for 30 days. Pesticide and diet quality made an impact on histopathological lesions. In treatments of deltamethrin, group fed with control diet showed much greater damage in comparison with group fed with vitamin E supplemented diet. Vitamin E decreased some histopathological changes induced by deltamethrin, but did not confer complete protection. Deltamethrin treatment has been shown to results in a significant increase in the frequency of micronucleus. However, coadministration of deltamethrin and vitamin E showed decrease in the frequency of micronucleus as compared to deltamethrin treated fish. Our results indicate that, the MN assay and histopathology can be used as bioassays for monitoring pollution in aquatic medium. On the other hand, it was observed that vitamin E decreased the genotoxicity and histopathological changes induced by deltamethrin. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDicle University [DUBAP-10-FF-12]en_US
dc.description.sponsorshipThis study was financially supported by Dicle University, Research Fund Project (Project no: DUBAP-10-FF-12).en_US
dc.identifier.doi10.1016/j.etap.2012.03.009
dc.identifier.endpage179en_US
dc.identifier.issn1382-6689
dc.identifier.issue2en_US
dc.identifier.pmid22534510
dc.identifier.scopus2-s2.0-84859932616
dc.identifier.scopusqualityQ1
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2012.03.009
dc.identifier.urihttps://hdl.handle.net/11468/15391
dc.identifier.volume34en_US
dc.identifier.wosWOS:000313155600007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin Een_US
dc.subjectHistopathologyen_US
dc.subjectMicronucleusen_US
dc.subjectFishen_US
dc.subjectDeltamethrinen_US
dc.subjectPyrethroid Pesticideen_US
dc.titleThe protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrinen_US
dc.titleThe protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrin
dc.typeArticleen_US

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