TLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 microsatellite gene polymorphism in patients with acute biliary pancreatitis: Does it cause the disease?

Basit Öğe Kaydı
dc.contributor.authorAnilir, Ender
dc.contributor.authorOzen, Filiz
dc.contributor.authorOzemir, Ibrahim Ali
dc.contributor.authorYildirim, Ibrahim Halil
dc.contributor.authorBilgic, Cagri
dc.contributor.authorAlimoglu, Orhan
dc.date.accessioned2024-04-24T17:27:32Z
dc.date.available2024-04-24T17:27:32Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: There has been coverage of Toll-like receptor 4 and Toll-like receptor 2 gene polymorphisms in inflammatory episodes in a number of studies. In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of mutations in Asp299Gly and Thr399Ile of the Toll-like receptor 4 gene, and the intron 2 microsatellite polymorphism of the Toll-like receptor 2 gene on the occurrence of acute biliary pancreatitis. Material and Methods: The study included 86 patients for the Toll-like receptor 4 Thr399Ile polymorphism, 100 patients for the Toll-like receptor 4 Asp299Gly polymorphism with acute biliary pancreatitis, and 101 healthy volunteers. At the same time, 93 patients and 92 healthy volunteers were included in the study to research the Toll-like receptor 2 intron 2 microsatellite polymorphism. Genotypes were determined using the restriction fragment length polymorphism analysis of PCR products and by an allele-specific PCR. Results: The Toll-like receptor 4 Thr399Ile homozygotes mutant variants (p=0.005) and Toll-like receptor 2 MM genotype (p<0.001) were detected with a significantly higher frequency in patients with acute biliary pancreatitis than in the healthy blood donors. Conclusion: The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and the Toll-like receptor 2 intron 2 microsatellite polymorphism are statistically associated with ABP.en_US
dc.identifier.doi10.5152/turkjsurg.2017.3828
dc.identifier.endpage197en_US
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue3en_US
dc.identifier.pmid30216179
dc.identifier.startpage191en_US
dc.identifier.trdizinid305737
dc.identifier.urihttps://doi.org/10.5152/turkjsurg.2017.3828
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/305737
dc.identifier.urihttps://hdl.handle.net/11468/20031
dc.identifier.volume34en_US
dc.identifier.wosWOS:000446227800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectBiliaryen_US
dc.subjectGene Polymorphismen_US
dc.subjectToll-Like Receptor 2en_US
dc.subjectToll-Like Receptor 4en_US
dc.titleTLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 microsatellite gene polymorphism in patients with acute biliary pancreatitis: Does it cause the disease?en_US
dc.titleTLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 microsatellite gene polymorphism in patients with acute biliary pancreatitis: Does it cause the disease?
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu