The experience from ten insulinoma cases

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dc.authorid0000-0002-5323-2257en_US
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorKılıç, Faruk
dc.contributor.authorTuna, Mazhar
dc.contributor.authorSoylu, Hikmet
dc.date.accessioned2023-10-30T06:34:22Z
dc.date.available2023-10-30T06:34:22Z
dc.date.issued2017en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Insulinoma is a rare, pancreatic functional neuroendocrine tumor, characterized by endogenous hyperinsulinemia, fasting hypoglycemia, and neuroglycopenic symptoms. It is diagnosed by a 72-h-fasting test, followed by localization studies. The common treatment option is the surgical excision. We hereby aim to discuss our clinical experience related to the patients of insulinoma. Material and Method: A retrospective analysis was done on the history of the patients, who were hospitalized to our clinic due to hypoglycemia and biochemically detected insulinoma (glucose [removed] 3 μU/mL and C-peptide >0.6 ng/mL), between June 2007 and May 2015. Findings: The average age of the patients was 52,6 and ranged from 18 to 85 years. Five patients were men and five were women. All of the patients presented with fasting hypoglycemia. In one patient, the tumor was detected by DOTATATE scintigraphy. Seven patients underwent surgery and were cured. One patient demonstrated metastasis. The tumor could not be localized by ultrasound, CT, and MRI in two patients, and therefore, they were subjected to surgery after localizing the tumor by advanced imaging methods. Discussion: In patients with fasting hypoglycemia and neuroglycopenia, along with Whipple’s triad, insulinoma should mainly be considered and a 72-h-fasting test should be conducted for diagnosis. The localization studies should be performed if the results are < 55 mg/dL for blood glucose, >3 μU/mL for insulin and > 0.6 ng/mL for C-peptide in blood sampled during the appearance of symptoms. We found that the triphasic thin slice CT, with multi-detector, was very useful for tumor localization in the test patients.en_US
dc.identifier.citationPekkolay, Z., Kılıç, F., Tuna, M. ve Soylu, H. (2017). The experience from ten insulinoma cases. Turkish Journal of Endocrinology and Metabolism, 21(3), 85-88.en_US
dc.identifier.doi10.25179/tjem.2017-56483
dc.identifier.endpage88en_US
dc.identifier.issn1301-2193
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85030128523
dc.identifier.scopusqualityQ4
dc.identifier.startpage85en_US
dc.identifier.trdizinidTRDizinIdYok
dc.identifier.urihttps://www.endocrinolrespract.org//en/the-experience-from-ten-insulinoma-cases-13350%5C
dc.identifier.urihttps://hdl.handle.net/11468/12991
dc.identifier.volume21en_US
dc.identifier.wosWOS:000417410900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorPekkolay, Zafer
dc.institutionauthorKılıç, Faruk
dc.institutionauthorTuna, Mazhar
dc.institutionauthorSoylu, Hikmet
dc.language.isoenen_US
dc.publisherTürkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypoglycemiaen_US
dc.subjectInsulinomaen_US
dc.subjectTriphasic CTen_US
dc.titleThe experience from ten insulinoma casesen_US
dc.titleThe experience from ten insulinoma cases
dc.title.alternativeBir Seri insülinoma olgusu: On hastadaki deneyimimizen_US
dc.title.alternativeBir Seri insülinoma olgusu: On hastadaki deneyimimiz
dc.typeArticleen_US

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