Assessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposure

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dc.contributor.authorElkama, Aylin
dc.contributor.authorSenturk, Kerem
dc.contributor.authorKarahalil, Bensu
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractGasoline station attendants are exposed to numerous chemicals that might have genotoxic and carcinogenic potential, such as benzene in fuel vapor and particulate matter and polycyclic aromatic hydrocarbons in vehicle exhaust emission. According to IARC, benzene and diesel particulates are Group 1 human carcinogens, and gasoline has been classified as Group 2A possibly carcinogenic to humans. At gas stations, self-service is not implemented in Turkey; fuel-filling service is provided entirely by employees, and therefore they are exposed to those chemicals in the workplace during all working hours. Genetic monitoring of workers with occupational exposure to possible genotoxic agents allows early detection of cancer. We aimed to investigate the genotoxic damage due to exposures in gasoline station attendants in Turkey. Genotoxicity was evaluated by the Comet, chromosomal aberration, and cytokinesis-block micronucleus assays in peripheral blood lymphocytes. Gasoline station attendants (n = 53) had higher tail length, tail intensity, and tail moment values than controls (n = 61). In gasoline station attendants (n = 46), the frequencies of chromatid gaps, chromosome gaps, and total aberrations were higher compared with controls (n = 59). Increased frequencies of micronuclei and nucleoplasmic bridges were determined in gasoline station attendants (n = 47) compared with controls (n = 40). Factors such as age, duration of working, and smoking did not have any significant impact on genotoxic endpoints. Only exposure increased genotoxic damage in gasoline station attendants independently from demographic and clinical characteristics. Occupational exposure-related genotoxicity risk may increase in gasoline station attendants who are chronically exposed to gasoline and various chemicals in vehicle exhaust emissions.en_US
dc.description.sponsorshipGazi University Scientific Research Projects [02/2019-19]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Gazi University Scientific Research Projects (Project No: 02/2019-19).en_US
dc.identifier.doi10.1177/07482337241247089
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.pmid38597775
dc.identifier.scopus2-s2.0-85190425589
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1177/07482337241247089
dc.identifier.urihttps://hdl.handle.net/11468/18085
dc.identifier.wosWOS:001200117800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosomal Aberrationsen_US
dc.subjectDna Damageen_US
dc.subjectGasolineen_US
dc.subjectGenotoxicityen_US
dc.subjectOccupational Exposureen_US
dc.titleAssessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposureen_US
dc.titleAssessment of genotoxicity biomarkers in gasoline station attendants due to occupational exposure
dc.typeArticleen_US

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