Neuroprotective Effects of Olanzapine in N-Methyl-D-Aspartate-Induced Retinal Injury

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dc.contributor.authorOnder, Halil Ibrahim
dc.contributor.authorAktan, Gulderen
dc.contributor.authorYuksel, Harun
dc.contributor.authorAvcioglu, Sedat
dc.contributor.authorYildirim, Umran
dc.contributor.authorKaya, Murat
dc.contributor.authorTunc, Murat
dc.date.accessioned2024-04-24T17:08:02Z
dc.date.available2024-04-24T17:08:02Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate the neuroprotective effect of olanzapine (OLA), an atypical antipsychotic drug, on N-methyl-D-aspartate (NMDA)-induced retinal injury. Methods: Retinal neuronal ischemia was induced by NMDA in Wistar rats. OLA was administered intraperitoneally in 2 different dosages: 2 and 12 mg/kg. At the end of 2 weeks of OLA treatment, 1 eye of each animal was enucleated for histopathologic examination. We also measured malondialdehyde (MDA) levels in retinal homogenates as a marker of ischemic injury. Results: The retinal ganglion cell (RGC) count was significantly higher in cases where we used OLA 2 mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0032 and P = 0.0005, respectively). We also found that MDA was significantly reduced by OLA 2mg/kg or OLA 12 mg/kg compared to the control group (P = 0.0001 and P = 0.0001, respectively). There was no statistically significant difference between OLA 2 mg/kg or OLA 12mg/kg groups in terms of RGC count and MDA levels (P > 0.05 for all). Conclusion: Our data showed that OLA preserved RGCs from NMDA-induced retinal injury; thus, it may have potential neuroprotective effects.en_US
dc.identifier.doi10.1089/jop.2012.0075
dc.identifier.endpage430en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue4en_US
dc.identifier.pmid23215752en_US
dc.identifier.scopus2-s2.0-84880526631en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2012.0075
dc.identifier.urihttps://hdl.handle.net/11468/17168
dc.identifier.volume29en_US
dc.identifier.wosWOS:000318221900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal of Ocular Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleNeuroprotective Effects of Olanzapine in N-Methyl-D-Aspartate-Induced Retinal Injuryen_US
dc.typeArticleen_US

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