Investigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury

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dc.contributor.authorDemirtas, Sinan
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYazici, Suleyman
dc.contributor.authorGuclu, Orkut
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorTezcan, Orhan
dc.contributor.authorKaplan, Ibrahim
dc.date.accessioned2024-04-24T16:15:24Z
dc.date.available2024-04-24T16:15:24Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate whether anticoagulant and antiaggregant agents have protective effects against oxidative damage induced by peripheral ischemia ereperfusion (I/R). Groups were created as follows: control group, I/R group (sham group), I/R plus acetylsalicylic acid (Group I), I/R+clopidogrel (Group II), I/R+rivaroxaban (Group III), I/R+bemiparin sodium (Group IV), and I/R+enoxaparin sodium (Group V). In Groups I, II, III, IV, and V, drugs were administered daily for 1 week before I/R creation. Peripheral I/R was induced in the I/R groups by clamping the right femoral artery. The rats were sacrificed 1 hour after reperfusion. Nitrogen oxide levels, malondialdehyde (MDA) levels, paraoxonase-1 (PON1) activity, and prolidase activity were evaluated in both cardiac and renal tissues. There was no significant difference in nitrogen oxide levels between the groups. However, cardiac and renal MDA were significantly higher and PON1 activity was markedly lower in the I/R groups compared with the control group (p < 0.05). Although elevated prolidase activity was detected in both the cardiac and renal tissue of the I/R groups, only the sham group and Group V had significantly higher renal prolidase activity (p < 0.05). Group V had significantly higher cardiac MDA, PON1, prolidase levels, and renal prolidase activity compared with the sham group (p < 0.05). Significant improvement in renal MDA levels was only observed in Group III, and marked improvement was observed in the cardiac MDA levels of Group II when compared with the sham group (p < 0.05). Thromboprophylactic agents appear to provide partial or prominent protection against I/R injury. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.kjms.2014.12.005
dc.identifier.endpage122en_US
dc.identifier.issn1607-551X
dc.identifier.issue3en_US
dc.identifier.pmid25744233
dc.identifier.scopus2-s2.0-84924622615
dc.identifier.scopusqualityQ1
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2014.12.005
dc.identifier.urihttps://hdl.handle.net/11468/15790
dc.identifier.volume31en_US
dc.identifier.wosWOS:000352087200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofKaohsiung Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiaggregant Drugsen_US
dc.subjectAnticoagulant Drugsen_US
dc.subjectCardioprotectionen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectRenoprotectionen_US
dc.titleInvestigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injuryen_US
dc.titleInvestigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury
dc.typeArticleen_US

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