Percutaneous removal of sentinel lymph nodes in a swine model using a breast lesion excision system and contrast-enhanced ultrasound

Basit Öğe Kaydı
dc.contributor.authorSever, Ali R.
dc.contributor.authorMills, Philippa
dc.contributor.authorHyvelin, Jean-Marc
dc.contributor.authorWeeks, Jennifer
dc.contributor.authorGumus, Hatice
dc.contributor.authorFish, David
dc.contributor.authorMali, Willem
dc.date.accessioned2024-04-24T16:00:07Z
dc.date.available2024-04-24T16:00:07Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives To investigate the feasibility of percutaneous removal of the entire sentinel lymph node (SLN) in an animal model using a breast lesion excision system after identifying these nodes using contrast-enhanced ultrasound (CEUS) and intradermal microbubbles. Methods Animal studies approval was obtained. SLNs were identified using CEUS and intradermal injection of microbubbles in two young pigs. Microbubbles were mixed with blue dye and injected around the mammary papillae to access lymphatic drainage to the superficial inguinal lymph nodes. When enhancing nodes were identified, the breast lesion excision system (BLES) was used to remove these nodes percutaneously. Both animals then underwent surgical lymph node dissection. Histopathological examination of all the samples was performed. Results Removal of the entire SLN was successful in three groins in the pigs. All three nodes were stained with blue dye. No other stained nodes were observed in the node dissection specimens. The nodal architecture of removed lymph nodes was well preserved on microscopy. There were no signs of excess trauma within the biopsy bed. Conclusion The results obtained from the swine model demonstrated that it is feasible to remove the entire SLN percutaneously under the guidance of CEUS and microbubbles.en_US
dc.description.sponsorshipBRACCO Imaging, S.p.A, Milan, Italyen_US
dc.description.sponsorshipWe would like to thank Prof. Francois Tranquart and Dr. Michel Schneider from BRACCO Suisse SA Imaging for inviting ARS, PM and HD to visit and perform this animal study in Bracco Suisse SA, Geneva Research Centre, and Dr Xavier Fouillet from Bracco Suisse for the histological analysis. BRACCO Imaging, S.p.A, Milan, Italy manufactured the contrast agent SonoVue T and financially supported the investigation. Dr. Jean-Marc Hyvelin works for BRACCO Suisse SA in the Geneva Research Centre. The biopsy equipment was supplied the Intact (R) breast lesion excision system (BLES, Intact Medical, Framingham, MA, USA).en_US
dc.identifier.doi10.1007/s00330-011-2293-1
dc.identifier.endpage550en_US
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.issue3en_US
dc.identifier.pmid21984418
dc.identifier.scopus2-s2.0-84856589927
dc.identifier.scopusqualityQ1
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.1007/s00330-011-2293-1
dc.identifier.urihttps://hdl.handle.net/11468/14376
dc.identifier.volume22en_US
dc.identifier.wosWOS:000299768000008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectExperimental Animal Modelsen_US
dc.subjectMicrobubblesen_US
dc.subjectSentinel Lymph Node Biopsyen_US
dc.subjectInterventional Ultrasonographyen_US
dc.titlePercutaneous removal of sentinel lymph nodes in a swine model using a breast lesion excision system and contrast-enhanced ultrasounden_US
dc.titlePercutaneous removal of sentinel lymph nodes in a swine model using a breast lesion excision system and contrast-enhanced ultrasound
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu