Low dose of isotretinoin: A comprehensive review

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dc.contributor.authorAbdelmaksoud, Ayman
dc.contributor.authorLotti, Torello
dc.contributor.authorAnadolu, Rana
dc.contributor.authorGoldust, Mohamed
dc.contributor.authorAyhan, Erhan
dc.contributor.authorDave, Dharmendra D.
dc.contributor.authorVestita, Michelangelo
dc.date.accessioned2024-04-24T17:11:27Z
dc.date.available2024-04-24T17:11:27Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIsotretinoin is a first-generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti-inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date-unlimited PubMed search, from inception till December 2019, using the following search terms: low-dose isotretinoin and dermatology, isotretinoin and safety, isotretinoin, off-label uses, isotretinoin and male fertility, isotretinoin, iPLEDGE system, aiming to deliver a therapeutic update relevant to clinical practice. All English-language articles were considered with no limitation based on the articles' type. Low-dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.en_US
dc.identifier.doi10.1111/dth.13251
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue2en_US
dc.identifier.pmid32022958en_US
dc.identifier.scopus2-s2.0-85079887286en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.13251
dc.identifier.urihttps://hdl.handle.net/11468/17523
dc.identifier.volume33en_US
dc.identifier.wosWOS:000514487300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDermatologyen_US
dc.subjectLow-Dose Isotretinoinen_US
dc.subjectSafetyen_US
dc.titleLow dose of isotretinoin: A comprehensive reviewen_US
dc.typeReview Articleen_US

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