Effects of N-acetyl-cysteine and acetylsalicylic acid on the tonsil bacterial biofilm tissues by light and electron microscopy

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dc.contributor.authorBulut, F.
dc.contributor.authorMeric, F.
dc.contributor.authorYorgancilar, E.
dc.contributor.authorNergiz, Y.
dc.contributor.authorAkkus, M.
dc.contributor.authorNergiz, S.
dc.contributor.authorNasir, Y.
dc.date.accessioned2024-04-24T17:33:42Z
dc.date.available2024-04-24T17:33:42Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The present study aimed to investigate the effects of the bacterial biofilm formation on the tonsil surface exposed N-acetyl-cysteine (NAC) and acetylsalicylic acid (ASA) of patients undergoing tonsillectomy by light and electron microscopy. The general process of biofilm formation comprises adhesion of free-living or planktonic bacteria to a surface, which subsequently develop into microcolonies and form a biofilm. Based on studies that have shown the presence of biofilms in common sites of chronic infections, it has become clear that bacteria may persist on mucosal surfaces through formation of biofilms. PATIENTS AND METHODS: Ten patients between 4 and 39 years of age (mean, 11.9 +/- 11.2 years). In all cases, periodic acide Schiff (PAS) staining was found to be an accurate predictor of the presence or absence of biofilm using light microscopy as a control standard. Therapeutic doses of NAC and ASA were identificated as the effective on the tonsil bacterial biofilm using light and electron microscopy. RESULTS: Biofilm formation was detected on all samples. Tonsils removed from patients with ASA-10 had showed higher-grade inhibitory effect at the biofilm formation than the other group (p <= 0.0001). The correlation was found between drug dose and decrease at the biofilm formation. CONCLUSIONS: In chronic or recurrent tonsillitis patients, decrease on the tonsils surface biofilm formation may be associated with ASA dose. Whether effect on the tonsils surface biofilm formation of other agent have a role is not known.en_US
dc.identifier.endpage3725en_US
dc.identifier.issn1128-3602
dc.identifier.issue23en_US
dc.identifier.pmid25535147
dc.identifier.scopus2-s2.0-84942284347
dc.identifier.scopusqualityQ2
dc.identifier.startpage3720en_US
dc.identifier.urihttps://hdl.handle.net/11468/20810
dc.identifier.volume18en_US
dc.identifier.wosWOS:000352210800029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectChronic Tonsillitisen_US
dc.subjectIn Vitroen_US
dc.subjectMucosal Biofilmen_US
dc.subjectN-Acetyl-Cysteineen_US
dc.titleEffects of N-acetyl-cysteine and acetylsalicylic acid on the tonsil bacterial biofilm tissues by light and electron microscopyen_US
dc.titleEffects of N-acetyl-cysteine and acetylsalicylic acid on the tonsil bacterial biofilm tissues by light and electron microscopy
dc.typeArticleen_US

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