Four decades without diagnosis: Sheehan's syndrome, a retrospective analysis

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dc.contributor.authorGokalp, Deniz
dc.contributor.authorAlpagat, Gulistan
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorTuzcu, Sadiye
dc.contributor.authorYakut, Fatime
dc.contributor.authorYildirim, Azad
dc.date.accessioned2024-04-24T16:24:43Z
dc.date.available2024-04-24T16:24:43Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Sheehan's syndrome (SS) remains a frequent cause of hypopituitarism in undeveloped and developing countries, but due to improvements in obstetric care, it is rare in developed countries. We aimed to share the results of a retrospective study analyzing the demographic, clinical, imaging, and hormonal characteristics of a large group of patients with SS, and also increase awareness of this syndrome especially in developed countries. Methods: The medical records of 124 patients with SS patients who were followed up in the Endocrinology Department of Dicle University between 1995 and 2015 were assessed retrospectively. Results: The mean period of diagnostic delay was 20.37 +/- 8.34 years on average. 5.7% of patients with SS were literate; 62% of patients delivered at home. Anemia was identified in 64.5% of SS patients. Mean blood sodium levels were 129.8 +/- 11.3 mEq/L. The mean urine densities were 1013 +/- 6.5. Osteoporosis and osteopenia were found in 44 (35.4%) and 71 (57.2%) patients, respectively, According to pituitary magnetic resonance imaging (MRI) analyses, 92 (74.2%) patients with SS had completely empty sella, 29 (23.3%) had partially empty sella, and 1 patient had microadenoma, and 2 had normal pituitary MRI results. Conclusions: Improved obstetric care and effective interventions for postpartum hemorrhage have limited the prevalence of SS in developed countries. However, in developing countries like Turkey, SS due to postpartum bleeding remains common. Thus, physician's awareness of the symptoms of SS is urgently required to avoid the associated morbidity and mortality.en_US
dc.identifier.doi10.1080/09513590.2016.1190331
dc.identifier.endpage907en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue11en_US
dc.identifier.pmid27252045
dc.identifier.scopus2-s2.0-84973154395
dc.identifier.scopusqualityQ2
dc.identifier.startpage904en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2016.1190331
dc.identifier.urihttps://hdl.handle.net/11468/16828
dc.identifier.volume32en_US
dc.identifier.wosWOS:000390160300010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothalamic Amenorrheaen_US
dc.subjectOsteoporosisen_US
dc.subjectPituitary Glanden_US
dc.titleFour decades without diagnosis: Sheehan's syndrome, a retrospective analysisen_US
dc.titleFour decades without diagnosis: Sheehan's syndrome, a retrospective analysis
dc.typeArticleen_US

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