The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients

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dc.authorid0000-0001-7657-3065en_US
dc.contributor.authorAkyüz, Abdurrahman
dc.contributor.authorIşık, Ferhat
dc.contributor.authorAslan, Burhan
dc.contributor.authorÇap, Murat
dc.contributor.authorKaya, İlyas
dc.contributor.authorAtlı, Özgür
dc.contributor.authorİnci, Ümit
dc.contributor.authorTaştan, Ercan
dc.contributor.authorAktan, Adem
dc.contributor.authorBilge, Önder
dc.contributor.authorOkşul, Metin
dc.contributor.authorAydın, Emre
dc.contributor.authorKarahan, Zülküf
dc.contributor.authorAltıntaş, Derya Deniz
dc.contributor.authorAltındağ, Rojhat
dc.contributor.authorAdıyaman, Mehmet Şahin
dc.contributor.authorAltıntaş, Bernas
dc.date.accessioned2021-05-21T08:49:55Z
dc.date.available2021-05-21T08:49:55Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionWOS:000648071100001
dc.descriptionPMID: 33955313
dc.description.abstractIntroduction We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients. Material and method Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. The patient groups ACEI, ARB and other antihypertensive drugs (non-ACEI/ARB) were compared regarding same parameters. Results Median age was 68 (60-76) years in the patient group including 805 (59.9.1%) females. Of the patients, 475 (35.3%), 644 (47.9%) and 226 (16.8%) were using ACEIs, ARBs and non-ACEI/ARB, respectively. AHRF and in-hospital mortality developed in 1053 (78.3%) and 290 (21.6%) patients, respectively. Age, gender, coronary artery disease, diabetes mellitus (DM), neutrophil, lymphocyte, creatinine, D-dimer, C-reactive protein (CRP), ACEI, beta blocker and aspartate transaminase (AST) found statistically significant in the univariable logistic regression performed to identify independent predictors of mortality were included multivariable logistic regression model. Age (OR: 1.066, 95%CI: 1.049-1.083; p < .001), DM (OR: 1.682, 95%CI: 1.238-2.286; p = .001), neutrophil (OR: 1.041, 95%CI: 1.007-1.077; p = .019), creatinine (OR: 1.178, 95%CI: 1.048-1.325; p = .006), CRP (OR: 1.008, 95%CI: 1.006-1.010; p < .001), ACEI (OR: 0.718, 95%CI: 0.521-0.988; p = .042), AST (OR: 1.005, 95%CI: 1.001-1.010; p = .010) were found associated with in-hospital mortality. Conclusion In our study, it was not detected clinically significant difference between three groups with regard to their relation with in-hospital mortality.en_US
dc.identifier.citationAkyüz, A., Işık, F., Aslan, B., Çap, M., Kaya, İ., Atlı, Ö. (2021). The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients. Clinical and Experimental Hypertension, 43(7), 587-596.en_US
dc.identifier.doi10.1080/10641963.2021.1916947
dc.identifier.endpage596
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue7
dc.identifier.pmid33955313
dc.identifier.scopus2-s2.0-85105974773
dc.identifier.scopusqualityQ2
dc.identifier.startpage587
dc.identifier.urihttps://www.tandfonline.com/doi/pdf/10.1080/10641963.2021.1916947?needAccess=true
dc.identifier.urihttps://hdl.handle.net/11468/6949
dc.identifier.volume43en_US
dc.identifier.wosWOS:000648071100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Emre
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofClinical and Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectACEIen_US
dc.subjectAcute hypoxemic respiratory failureen_US
dc.subjectARBen_US
dc.subjectCovid-19 infectionen_US
dc.subjectHypertensionen_US
dc.subjectİn-hospital mortalityen_US
dc.titleThe effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patientsen_US
dc.titleThe effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients
dc.typeArticleen_US

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