Tetanus in adults: results of the multicenter ID-IRI study

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dc.contributor.authorTosun, S.
dc.contributor.authorBatirel, A.
dc.contributor.authorOluk, A. I.
dc.contributor.authorAksoy, F.
dc.contributor.authorPuca, E.
dc.contributor.authorBenezit, F.
dc.contributor.authorUral, S.
dc.date.accessioned2024-04-24T16:02:01Z
dc.date.available2024-04-24T16:02:01Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractTetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital's Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival.en_US
dc.identifier.doi10.1007/s10096-017-2954-3
dc.identifier.endpage1462en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue8en_US
dc.identifier.pmid28353183
dc.identifier.scopus2-s2.0-85016094626
dc.identifier.scopusqualityQ1
dc.identifier.startpage1455en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-017-2954-3
dc.identifier.urihttps://hdl.handle.net/11468/14578
dc.identifier.volume36en_US
dc.identifier.wosWOS:000406290100014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleTetanus in adults: results of the multicenter ID-IRI studyen_US
dc.titleTetanus in adults: results of the multicenter ID-IRI study
dc.typeArticleen_US

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