Phytochemical Analysis and Assessment of Antioxidant and Enzyme Inhibitory Activity of Alchemilla pseudocartalinica Juz.

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dc.authoridSEYHAN, GOKCE/0000-0002-8553-9093
dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.authoridGOKKAYA, ICIM/0000-0003-0803-2886
dc.contributor.authorUzunkaya, Cagla
dc.contributor.authorGokkaya, Icim
dc.contributor.authorAkkaya, Didem
dc.contributor.authorSoral, Michal
dc.contributor.authorSeyhan, Gokce
dc.contributor.authorBarut, Burak
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.date.accessioned2025-02-22T14:09:11Z
dc.date.available2025-02-22T14:09:11Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to evaluate and compare the antioxidant capacity and enzyme inhibitory activity of extracts, sub-extracts, and fractions prepared from the aerial parts and roots of A. pseudocartalinica. The phytochemical content of the active extracts was also analyzed. According to the results, ellagic acid (38.42 mg/g) was the major compound in the aerial part methanol extract and catechin (185.30 mg/g) in the root methanol extract. The DPPH inhibition activity of all fractions was monitored, with the most active one (Fr B) reaching an IC50 value of (4.92 +/- 0.59 mu g/mL). All the fractions prepared from the aerial parts' water sub-extract showed higher a-glucosidase inhibitory activity than the positive control acarbose. In the tyrosinase assay, Fr B (58.81 +/- 7.50 mu g/mL) exhibited the highest inhibitory actions among all fractions. The structure of the major substances of the most active fraction were elucidated as quercetin 7-O-beta-glucopyranosyl-3-O-beta-glucuronopyranoside- (1), and alpha-[(2-formyl-5-hydroxymethyl)pyrrol-1-yl]aspartic acid (2).en_US
dc.description.sponsorshipScientific Research Foundation of Karadeniz Technical University; Scientific Grant Agency of the Ministry of Education, Research, Development and Youth of the Slovak Republic; Slovak Academy of Sciences (VEGA) [2/0118/23]; [TYL-2023-10648]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Foundation of Karadeniz Technical University (Project number: TYL-2023-10648) and by the Scientific Grant Agency of the Ministry of Education, Research, Development and Youth of the Slovak Republic and of the Slovak Academy of Sciences (VEGA) [Project no. 2/0118/23]. This study was presented as a poster presentation in the form of a summary at the PSE Natural drug discovery: Current approach and future perspectives conference.en_US
dc.identifier.doi10.1002/cbdv.202401217
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39344428en_US
dc.identifier.scopus2-s2.0-85208447687en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202401217
dc.identifier.urihttps://hdl.handle.net/11468/29825
dc.identifier.wosWOS:001357622000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectAlchemilla pseudocartalinicaen_US
dc.subjectalpha-Glucosidase inhibitoryen_US
dc.subjectBiological activity guided fractionationen_US
dc.subjectRosaceaeen_US
dc.subjectTyrosinaseen_US
dc.titlePhytochemical Analysis and Assessment of Antioxidant and Enzyme Inhibitory Activity of Alchemilla pseudocartalinica Juz.en_US
dc.typeArticleen_US

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