Epidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study

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dc.contributor.authorDundar, Devrim
dc.contributor.authorWillke, Ayse
dc.contributor.authorSayan, Murat
dc.contributor.authorKoc, Meliha Meric
dc.contributor.authorAkan, Ozay Arikan
dc.contributor.authorSumerkan, Bulent
dc.contributor.authorSaltoglu, Nese
dc.date.accessioned2024-04-24T16:15:06Z
dc.date.available2024-04-24T16:15:06Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the epidemiological and molecular features of clinical meticillin-resistant Staphylococcus aureus (MRSA) isolates in Turkey. MRSA isolates were collected from six regions of Turkey. The mecA and nuc genes were detected by PCR. Antimicrobial susceptibilities were determined by the disk diffusion method. Staphylococcal cassette chromosome mec (SCCmec) and staphylococcal protein A (spa) typing were performed by the sequencing method for 270 randomly selected MRSA isolates. The US Centers for Disease Control and Prevention (CDC) definition was used for epidemiological diagnosis of community-associated MRSA (CA-MRSA). Resistance rates of MRSA to ciprofloxacin, gentamicin, clindamycin, erythromycin, rifampicin, trimethoprim/sulfamethoxazole and tetracycline were 93.4%, 81.2%, 38.5%, 57.8%, 93.9%, 1.1% and 93.1%, respectively. The most frequent SCCmec type was SCCmec III (91.1%). SCCmec type IV was found in 5.2% of the isolates. The most frequent spa type was t030 (81.1%). Five isolates were CA-MRSA if only the epidemiological definition was used (5/725; 0.7%). Two isolates were defined as CA-MRSA both by epidemiological features and SCCmec typing (2/270; 0.7%). Of 14 SCCmec type IV isolates, 12 were not defined as CA-MRSA by epidemiological features. In conclusion, this is the most comprehensive multicentre study in Turkey investigating MRSA using both epidemiological and genotypic features. The CA-MRSA rate is low in Turkey. Combined use of epidemiological and genotypic methods is the most accurate approach for the diagnosis of CA-MRSA. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Unit of Kocaeli University (Kocaeli, Turkey) [2005/3]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Unit of Kocaeli University (Kocaeli, Turkey) [2005/3].en_US
dc.identifier.doi10.1016/j.jgar.2016.02.006
dc.identifier.endpage49en_US
dc.identifier.issn2213-7165
dc.identifier.issn2213-7173
dc.identifier.pmid27530838
dc.identifier.scopus2-s2.0-84962892969
dc.identifier.scopusqualityQ1
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1016/j.jgar.2016.02.006
dc.identifier.urihttps://hdl.handle.net/11468/15645
dc.identifier.volume6en_US
dc.identifier.wosWOS:000381918100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Global Antimicrobial Resistance
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMrsaen_US
dc.subjectEpidemiologyen_US
dc.subjectMolecular Characteristicsen_US
dc.titleEpidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre studyen_US
dc.titleEpidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study
dc.typeArticleen_US

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