Sociodemographic, clinical, laboratory, treatment and prognostic characteristics of 156 generalized pustular psoriasis patients in Turkey: a multicentre case series

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dc.authorid0000-0003-0675-5204en_US
dc.contributor.authorPolat, A. Kara
dc.contributor.authorAlpsoy, E.
dc.contributor.authorKalkan, G.
dc.contributor.authorAytekin, S.
dc.contributor.authorUçmak, D.
dc.contributor.authorGüner, R. Yasak
dc.date.accessioned2023-03-30T12:44:02Z
dc.date.available2023-03-30T12:44:02Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground Generalized pustular psoriasis (GPP) is a rare and severe inflammatory disease characterized by widespread and superficial sterile pustules on an erythematous background. Objectives This multicentre study aimed to determine the clinical profile and course in a large cohort of patients with GPP. Methods One hundred and fifty-six GPP patients (mean age, 44.2 +/- 18.7 years) who met the diagnostic criteria of the European Consensus Report of GPP were included in the study. Sociodemographic characteristics, quality of life, triggering factors of the disease, clinical, laboratory, treatment and prognostic features were evaluated. Results 61.5% of the patients were female. The rate of working at or below the minimum wage (<=$332.5/month) was 44.9%. Drugs (36.5%) were the most common trigger. While hypocalcaemia (35.7%) was the most important cause of GPP during pregnancy, systemic steroid withdrawal (20%) was the most frequently reported trigger for infantile/juvenile and mixed-type GPP (15%) (P < 0.05). Acute GPP (53.8%) was the most common clinic. Nails were affected in 43.6% of patients, and subungual yellow spots (28.2%) were the most common change. In annular GPP, fever (P < 0.001) and relapse frequency (P = 0.006) were lower than other subtypes, and the number of hospitalizations (P = 0.002) was lower than acute GPP. GPP appeared at a later age in those with a history of psoriasis (P = 0.045). DLQI score (P = 0.049) and joint involvement (P = 0.016) were also higher in this group. Infantile/juvenile GPP was observed in 16.02% of all patients, and arthritis was lower in this group (24.4 vs. 16%). GPP of pregnancy had the worst prognosis due to abortion observed in three patients. Conclusions Recent advances in treatment have improved mortality associated with GPP, but abortion remains a significant complication. Although TNF-alpha inhibitors have proven efficacy in GPP, they can also trigger the disease. Mixed-type GPP is more similar to acute GPP than annular GPP with systemic manifestations and course.en_US
dc.identifier.citationPolat, A.K., Alpsoy, E., Kalkan, G., Aytekin, S., Uçmak, D., Güner, R.Y. ve diğerleri. (2022). Sociodemographic, clinical, laboratory, treatment and prognostic characteristics of 156 generalized pustular psoriasis patients in Turkey: a multicentre case series. Journal of the European Academy of Dermatology and Venereology, 36(8), 1256-1265.en_US
dc.identifier.doi10.1111/jdv.18103
dc.identifier.endpage1265en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue8en_US
dc.identifier.pmid35348254
dc.identifier.scopus2-s2.0-85128212283
dc.identifier.scopusqualityQ1
dc.identifier.startpage1256en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.18103
dc.identifier.urihttps://hdl.handle.net/11468/11569
dc.identifier.volume36en_US
dc.identifier.wosWOS:000782013600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçmak, Derya
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFeaturesen_US
dc.subjectDiagnosisen_US
dc.subjectZumbuschen_US
dc.subjectProfileen_US
dc.subjectJohoren_US
dc.titleSociodemographic, clinical, laboratory, treatment and prognostic characteristics of 156 generalized pustular psoriasis patients in Turkey: a multicentre case seriesen_US
dc.titleSociodemographic, clinical, laboratory, treatment and prognostic characteristics of 156 generalized pustular psoriasis patients in Turkey: a multicentre case series
dc.typeArticleen_US

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