Is intralipid fat emulsion a promising therapeutic strategy on neurotoxicity induced by malathion in rats?

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dc.contributor.authorBasarslan, S. K.
dc.contributor.authorAlp, H.
dc.contributor.authorSenol, S.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorOzkan, U.
dc.date.accessioned2024-04-24T17:37:35Z
dc.date.available2024-04-24T17:37:35Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: Malathion is one of the most widely used organophosphate pesticides and herbicides. It has given rise to major clinical problems by its poisoning in all over the world. Malathion also a highly lipophilic agent, and tends to accumulate within lipid-rich tissue like a brain in the body, causing toxicity. Therefore, the study was aimed to investigate if there is a possible beneficial effect of using intralipid fat emulsion (IFE) on the neurotoxicity, and to detect it time-dependently at the beginning, 6th and 12th hours of M intoxication. MATERIALS AND METHODS: Forty-eight rats were randomly divided into six groups including: control (C), Lipid (L) group (18.6 mL/kg oral IFE), Malathion (M) group (10 mg/kg oral M), M0L group (IFE treated after immediate from M), M6L group (IFE treated after 6 hours from M), M12L group (IFE treated after 12 hours from M). RESULTS: M group in comparison with all others group, there was an increase in the total oxidant status (TOS) level. M group in comparison with C, L, M0L groups, it was seen significantly decrease in the total antioxidant capacity (TAC) level. Interestingly, M group in comparison with M6L and M12L groups, there was no significant difference among these groups in terms of the TAC levels. Although there was no significant difference among C, L and M0L groups in terms of both TAC and TOS levels, but was significant difference C, L groups in comparison with M6L, M12L groups in terms of TAC levels. C group in comparison with L, M0L, M6L, M12L groups in terms of TOS levels, there was no significant difference. These findings have indicated that IFE seriously reduced TOS levels in all the groups depending on time. Also, M0L group in comparison with M6L and M12L groups, there was significantly increase of the TAC levels. There was no statistically significant difference between M6L and M12L groups. These biochemical results were confirmed with immunohistochemical results. CONCLUSIONS: The study has had some certain evidence that IFE is a promising safe therapy for acutely intoxicated cases by organophosphate. It is much more effective if used at the beginning of organophosphate poisoning. As such, there is no need to avoid using IFE in clinical practice.en_US
dc.identifier.endpage476en_US
dc.identifier.issn1128-3602
dc.identifier.issue4en_US
dc.identifier.pmid24610612
dc.identifier.scopus2-s2.0-84896957961
dc.identifier.scopusqualityQ2
dc.identifier.startpage471en_US
dc.identifier.urihttps://hdl.handle.net/11468/21047
dc.identifier.volume18en_US
dc.identifier.wosWOS:000341967600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalathionen_US
dc.subjectIntralipid Fat Emulsionen_US
dc.subjectNeurotoxicityen_US
dc.subjectOrganophosphate Intoxicationen_US
dc.subjectRaten_US
dc.titleIs intralipid fat emulsion a promising therapeutic strategy on neurotoxicity induced by malathion in rats?en_US
dc.titleIs intralipid fat emulsion a promising therapeutic strategy on neurotoxicity induced by malathion in rats?
dc.typeArticleen_US

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