Expression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features

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dc.contributor.authorYaldiz, M
dc.contributor.authorHakverdi, AU
dc.contributor.authorBayhan, G
dc.contributor.authorAkkus, Z
dc.date.accessioned2024-04-24T17:33:55Z
dc.date.available2024-04-24T17:33:55Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin-embedded tissue specimens of cervical squamous carcinoma and the relationship with histopathological differentiation and lymph node status. Methods: In this study, we investigated by immunohistochemistry E-cadherin expression in ten normal cervical epithelia and 24 cervical invasive squamous carcinomas. Results: Normal cervical squamous epithelium showed strong expression of E-cadherin at the membrane of the cell and intercellular junctions. In 24 tumors immunnostained by E-cadherin antibody, 11 (46%) showed preserved expression and 13 (54%) reduced expression. There was no significant correlation between E-cadherin expression and histological differentiation (p = 0.650, p = 0.294). In the status of lymph node metastasis, reduced expression of E-cadherin was seen in 11/15 (73%) with lymph node metastasis versus 2/9 (22%) without lymph node metastasis. There was a significant inverse correlation between E-cadherin expression and lymph node metastasis (p = 0.032). Conclusion: Reduced E-cadherin expression may be an important factor among a variety of biologic events that occur during the process of metastasis. However, this should be explored by a large scale study.en_US
dc.identifier.endpage98en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid15755011
dc.identifier.scopus2-s2.0-14644411009
dc.identifier.scopusqualityN/A
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/11468/20890
dc.identifier.volume26en_US
dc.identifier.wosWOS:000227340800019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervixen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectE-Cadherinen_US
dc.titleExpression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological featuresen_US
dc.titleExpression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features
dc.typeArticleen_US

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