FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey

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dc.contributor.authorBalkan, Mahmut
dc.contributor.authorGedik, Abdullah
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorAy, Ozlem Izci
dc.contributor.authorErdal, M. Emin
dc.contributor.authorIsi, Hilmi
dc.contributor.authorBudak, Turgay
dc.date.accessioned2024-04-24T17:12:06Z
dc.date.available2024-04-24T17:12:06Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe influence of FSH receptor (FSHR) variants on male infertility is not completely understood. The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey. The SNPs in codon 680 and at position -29 of the FSHR gene were analyzed by PCR-RFLP technique in 240 men with proven fathers, and 270 infertile men (150 nonobstructive azoospermic and 120 severe oligozoospermic). The separate analysis for SNP at nucleotide position -29 did not show any difference in genotypic frequencies and serum FSH levels. The genotype distribution of SNP at position 680 was different but does not influence serum FSH levels. Together the two SNPs form four discrete haplotypes (A-Thr-Asn, G-Thr-Asn, A-Ala-Ser, and G-Ala-Ser) occurring in 10 combinations. A statistically significant difference in the allelic distribution of G-Asn/G-Ser and G-Ser/G-Ser genotype between proven fathers and infertile men but there were not any statistically significant difference in the overall frequency of the four FSHR haplotypes. We conclude that the FSHR haplotype does not associate with different serum FSH levels but it is differently distributed in proven fathers and infertile men.en_US
dc.identifier.doi10.1155/2010/640318
dc.identifier.issn1110-7243
dc.identifier.pmid20454649
dc.identifier.scopus2-s2.0-77952480337
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1155/2010/640318
dc.identifier.urihttps://hdl.handle.net/11468/17853
dc.identifier.wosWOS:000278462100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofJournal of Biomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleFSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkeyen_US
dc.titleFSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey
dc.typeArticleen_US

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