Relationship between serum leptin level and disease activity in patients with systemic sclerosis

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dc.contributor.authorBudulgan, Mahmut
dc.contributor.authorDilek, Banu
dc.contributor.authorDag, Sevin Buluttekin
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorYildiz, Ismail
dc.contributor.authorSariyildiz, Mustafa Akif
dc.contributor.authorCevik, Remzi
dc.date.accessioned2024-04-24T16:02:00Z
dc.date.available2024-04-24T16:02:00Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo determine the relationship between serum leptin levels and disease activity in systemic sclerosis (SSc). A total of 60 subjects (30 controls and 30 patients) were included. The inflammatory markers and leptin levels were evaluated and body mass index (BMI) was measured for both groups. The assessment of the skin involvement was performed based on the modified Rodnan skin score (mRSS). Disease activity was evaluated according to the Valentini scleroderma disease activity index. There was a significant difference between the patient and control groups in terms of BMI (p < 0.05); however there was no difference with regards to age and gender (p > 0.05). Valentini scores and mRSS were determined to be significantly higher in active patients (n = 14) than in inactive patients (n = 16) (p < 0.05). No significant difference was determined between groups in terms of leptin levels (p > 0.05). However, leptin levels were significantly lower in active patients than in inactive patients (p < 0.05). We found a significant positive correlation between serum leptin and BMI (p < 0.05), and leptin and serum C3 levels (p < 0.05); no relationship was detected between leptin and other parameters. Leptin can be used as an activity marker in SSc. Further studies, including larger series, should be carried out to clarify this relationship.en_US
dc.identifier.doi10.1007/s10067-013-2459-0
dc.identifier.endpage339en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue3en_US
dc.identifier.pmid24370646
dc.identifier.scopus2-s2.0-84896494072
dc.identifier.scopusqualityQ1
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-013-2459-0
dc.identifier.urihttps://hdl.handle.net/11468/14559
dc.identifier.volume33en_US
dc.identifier.wosWOS:000332485400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBmien_US
dc.subjectDisease Activityen_US
dc.subjectLeptinen_US
dc.subjectSystemic Sclerosisen_US
dc.titleRelationship between serum leptin level and disease activity in patients with systemic sclerosisen_US
dc.titleRelationship between serum leptin level and disease activity in patients with systemic sclerosis
dc.typeArticleen_US

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