Protective effects of melatonin on spinal cord injury

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dc.authorid0000-0002-7814-822Xen_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorBaran, Özlem
dc.contributor.authorÇiçekçi, Esra
dc.contributor.authorDönder, Ahmet
dc.contributor.authorAtiç, Ramazan
dc.contributor.authorDeveci, Engin
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2022-12-12T06:36:12Z
dc.date.available2022-12-12T06:36:12Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractSpinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury (100 g/cm force) T10at Melatonin (10 mg/kg intraperitoneally) was administered for 10 days after trauma. Each group consisted of 10 animals. of these, six were used for biochemical and four were used for th e evaluation of histological analysis. Spinal cord samples were taken for histological examination or determination of malondiald ehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. Spinal cord injury and melatonin treated group were compared. Melatonin administration in spinal cord injury increased the activity of glial cells in the radial and funicular cells and epen dymal cells and increased the activity of glial cells and also showed a positive ef fect on inflammation and vascular endothelial cells in s ynaptic connections in the nerve fibers undergoing spinal injury endothelial degeneration It is thought that it can regulate the degenerative effect which is caused by both the inflammatory effect and the angiogenic effect which will have a positive effect on the neural connection.en_US
dc.description.abstractRESUMEN: La lesión de la médula espinal (SCI) provoca daño en la fibra nerviosa, que puede conducir a alteraciones motoras y sensitivas, incluso la muerte. El objetivo de este estudio fue investigar los efectos neuroprotectores, proinflamatorios y proangiogénicos de la melatonina en un modelo de SCI inducida en rata. Para tal efecto se utilizaron dos grupos: Grupo 1 (n:10) se le indujo una SCI, mediante el método de reducción de peso estándar (100 g/cm fuerza), provocando una lesión de severidad moderada. Grupo 2 (n:10) inducción SCI más aplicación de T10 Melatonina (10 mg / kg v.i.) durante 10 días después del trauma. Muestras de seis animales de cada grupo fueron usados para análisis bioquímicos y los otros cuatro para la evaluación histológica. Se tomaron muestras de médula espinal para el examen histológico y para la determinación de niveles de malondialdehído (MDA) y glutatión (GSH), actividad mieloperoxidasa (MPO) y se comparó la lesión de la médula espinal y el grupo tratado con melatonina. La administración de melatonina en la lesión de la médula espinal aumentó la actividad de las células gliales en las células radiales, funiculares y ependimocitos. Ademas mostró un efecto positivo sobre la inflamación y angiogénesis en las conexiones sinápticas en las fibras nerviosas sometidas a lesión espinal. Pudiendo este participar en la regulación del efecto degenerativo causado, principalmente, por acción de angiogénesis e inflamación local.
dc.identifier.citationBaran, Ö., Çiçekçi, E., Dönder, A., Atiç, R., Deveci, E. ve Tuncer, M. C. (2018). Protective effects of melatonin on spinal cord injury. International Journal of Morphology, 36(2). 488-492.en_US
dc.identifier.doi10.4067/S0717-95022018000200488en_US
dc.identifier.endpage492en_US
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85049786940en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage488en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000200488&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/11016
dc.identifier.volume36en_US
dc.identifier.wosWOS:000438815300019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBaran, Özlem
dc.institutionauthorDönder, Ahmet
dc.institutionauthorAtiç, Ramazan
dc.institutionauthorDeveci, Engin
dc.institutionauthorTuncer, Mehmet Cudi
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelin-1en_US
dc.subjectMelatoninen_US
dc.subjectSpinal cord injuryen_US
dc.subjectTNF-αen_US
dc.titleProtective effects of melatonin on spinal cord injuryen_US
dc.title.alternativeEfectos protectores de la melatonina en lesión de la médula espinalen_US
dc.typeArticleen_US

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