Prognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma

Basit Öğe Kaydı
dc.contributor.authorBuyukbayram, H
dc.contributor.authorCureoglu, S
dc.contributor.authorArslan, A
dc.contributor.authorIsikakdogan, AR
dc.date.accessioned2024-04-24T17:07:55Z
dc.date.available2024-04-24T17:07:55Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the prognostic significance of p53, and proliferative cell nuclear antigen (PCNA) in laryngeal squamous cell carcinoma (LSCC). Sixty pathologic specimens from the patients with LSCC were examined for the expression of the p53 and PCNA, with complete follow-up data. Sixty-three percent of the cases displayed nuclear p53 overexpression. There was a correlation between p53 overexpression and histological grades (p=0.03), and localization site (p=0.05). Median of PCNA index was 42.2 (range 5.9 to 85.2). There was no difference between the p53 overexpression group and the normal group in proliferative activity determined by PCNA (p=0.73). In univariate analyses, localization site, grade, stage, invasion pattern, lymph node status, were significant factors in estimating disease free survival (DFS). Grade was the most important factor affecting recurrence (p=0.002). In multivariate analyses, grade was the only significant predictor for DFS (p=0.001). Grade (p=0.001) and invasion pattern (p=0.03) were found to be significant predictors of overall survival. In conclusion, the histological grade was the most reliable important prognostic factor. Further studies are necessary to facilitate understanding of the mechanisms of laryngeal carcinogenesis.en_US
dc.identifier.doi10.1081/CNV-120030207
dc.identifier.endpage202en_US
dc.identifier.issn0735-7907
dc.identifier.issn1532-4192
dc.identifier.issue2en_US
dc.identifier.pmid15199601
dc.identifier.scopus2-s2.0-2642549983
dc.identifier.scopusqualityQ3
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1081/CNV-120030207
dc.identifier.urihttps://hdl.handle.net/11468/17090
dc.identifier.volume22en_US
dc.identifier.wosWOS:000221848500004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCancer Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaryngeal Squamous Cell Carcinomaen_US
dc.subjectP53en_US
dc.subjectPcnaen_US
dc.subjectSurvivalen_US
dc.titlePrognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinomaen_US
dc.titlePrognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu