Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: An electrophysiological study

Basit Öğe Kaydı
dc.contributor.authorYilmaz, Tevfik
dc.contributor.authorAkca, Metehan
dc.contributor.authorTuran, Yahya
dc.contributor.authorOcak, Hakan
dc.contributor.authorKamasak, Kagan
dc.contributor.authorYildirim, Mehmet
dc.date.accessioned2024-04-24T16:10:57Z
dc.date.available2024-04-24T16:10:57Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractCorticosteroids are extensively used in treatment of many diseases. In neurosurgery practice, dexamethasone (DEX) is commonly used particularly in cerebral edema secondary to brain tumors, head trauma, and central nervous system infections. There are some uncertainties surrounding the secure use of DEX in patients with epilepsy or seizures induced by diseases of the central nervous system such as head trauma and brain tumors. Despite its extensive use, the effect of DEX on epileptiform activity is unclear. In this study the effect of DEX on epileptiform activity was investigated in rats. The effects of 1, 3, and 10 mg/kg DEX on epileptiform activity was compared with effects of antiepileptic drugs commonly employed in treatment of epilepsy, namely phenytoin (PHT) 50 mg/kg and levetiracetam (LEV) 50 mg/kg that were administered intraperitoneally for 1 week. All groups were administered intracortical penicillin (500 IU) to induce epileptiform activity. DEX at the doses of 3 mg/kg and 10 mg/kg significantly reduced spike frequencies compared to the initial values. In conclusion, we think that DEX can effectively decrease the epileptiform activity. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2014.01.040
dc.identifier.endpage72en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid24495842
dc.identifier.scopus2-s2.0-84895157734
dc.identifier.scopusqualityQ2
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2014.01.040
dc.identifier.urihttps://hdl.handle.net/11468/15200
dc.identifier.volume1554en_US
dc.identifier.wosWOS:000334476800008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexamethasoneen_US
dc.subjectPhenytoinen_US
dc.subjectLevetiracetamen_US
dc.subjectExperimental Epilepsyen_US
dc.subjectPenicillinen_US
dc.subjectRaten_US
dc.titleEfficacy of dexamethasone on penicillin-induced epileptiform activity in rats: An electrophysiological studyen_US
dc.titleEfficacy of dexamethasone on penicillin-induced epileptiform activity in rats: An electrophysiological study
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu