Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum

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dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorAgacayak, Elif
dc.contributor.authorBudak, Sukru
dc.contributor.authorTunc, Nurettin
dc.contributor.authorIcen, Mehmet Sait
dc.contributor.authorFindik, Fatih Mehmet
dc.contributor.authorEkinci, Aysun
dc.date.accessioned2024-04-24T17:11:44Z
dc.date.available2024-04-24T17:11:44Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To investigate whether serum levels of neopterin and inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG) compared to asymptomatic pregnant women. Methods: This cross-sectional study was performed including 30 pregnant women with HG (mean age: 30.67 +/- 6.68) and 30 asymptomatic pregnant women (mean age: 28.00 +/- 5.30). Demographic features, obstetric history, and the Pregnancy Unique Quantification of Emesis/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay and measurement of CRP, TNF-alpha, IL-6, total antioxidant status and total oxidative status (TOS) levels were taken and compared between groups. Results: White blood cell count (P = 0.013), platelet count (P = 0.015), TOS (P < 0.001), and PUQE score (P < 0.001) were remarkably higher in HG pregnancies. On the other hand, serum levels of lactate dehydrogenase, (P < 0.001), sodium (P < 0.001), potassium (P < 0.001), chloride (P < 0.001) and TAS (P < 0.001) were higher in the control group. There was no difference in the levels of neopterin, CRP, TNF-alpha and IL-6. In patients with HG, a positive correlation was detected between TOS and serum levels of lactate dehydrogenase, while TNF-alpha, IL-6 and neopterin were positively correlated with hemoglobin levels. Conclusion: Our results demonstrated no association between inflammation and HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes in HG necessitates further trials on larger series.en_US
dc.description.sponsorshipDicle University Scientific Research Commission [14-TF-61]en_US
dc.description.sponsorshipThis research was funded by the Dicle University Scientific Research Commission (grant number 14-TF-61). The authors are grateful to the Dicle University Department of Obstetrics and Gynecology and the Diyarbakir Maternity and Child Health Hospital, Department of Obstetrics and Gynecology for their valuable support.en_US
dc.identifier.doi10.1111/jog.12949
dc.identifier.endpage624en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue6en_US
dc.identifier.pmid26834047
dc.identifier.scopus2-s2.0-84957603994
dc.identifier.scopusqualityQ2
dc.identifier.startpage618en_US
dc.identifier.urihttps://doi.org/10.1111/jog.12949
dc.identifier.urihttps://hdl.handle.net/11468/17700
dc.identifier.volume42en_US
dc.identifier.wosWOS:000379847000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectHyperemesis Gravidarumen_US
dc.subjectInflammationen_US
dc.subjectNeopterinen_US
dc.subjectOxidative Stressen_US
dc.titleSerum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarumen_US
dc.titleSerum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum
dc.typeArticleen_US

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