Evaluation of bleeding symptoms and laboratory parameters related to bleeding in sisters of patients with hemophilia A and B

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dc.authorid0000-0003-2090-4392en_US
dc.authorid0000-0001-1456-5625en_US
dc.authorid0000-0001-5673-8408en_US
dc.contributor.authorAkdeniz, Nadiye
dc.contributor.authorKarakuş, Abdullah
dc.contributor.authorYıldız, İsmail
dc.contributor.authorAyyıldız, Mehmet Orhan
dc.date.accessioned2022-07-04T12:13:41Z
dc.date.available2022-07-04T12:13:41Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Hematoloji Bölümüen_US
dc.descriptionWOS:000636456800011
dc.descriptionPMID: 33390328
dc.description.abstractIntroduction: Our purpose was to determine the bleeding risk of obligate and potential carriers, highlight the prophylactic applications before interventions for families and physicians. Method: Forty-six sisters who had at least one family member with hemophilia A or B were included. Laboratory parameters were tested.Bleeding tendency interrogated by a detailed questionnaire.The results were compared with 43 healthy female controls. Results: Mean factor activity levels were significantly lower in sisters than control subjects (p = 0,004). Bleeding score was higher in sisters than controls (p = 0.001). Prolonged bleeding after minor injury was significantly higher in the sisters than control subjects (p = 0.008). Requiring further treatment due to prolonged bleeding after tooth extraction was significantly higher in sisters (p = 0.001). Sisters had postpartum hemorrhage lasting longer than 6 weeks than controls (p = 0.025). Menstrual period lasted longer in the sisters than controls (p < 0.001). Spontaneous epistaxis, oral and gingival bleeding were more frequently observed in sisters whose factor activity levels were 60 % or below (p = 0.014 and p = 0.047, respectively). There was no statistically significant difference between the severity of hemophilia in the affected family member and the factor levels in the sisters (p = 0.398).Spontaneous epistaxis has found to be significantly associated with the hemophilia severity in the family (p = 0.004). Conclusion: Clotting factor levels were found to be lower in the sisters and associated with spontaneous epistaxis, oral and gingival bleeding.Also, regardless of clotting factor levels, sisters significantly experienced more bleeding problems.Our study demonstrated the importance of taking precautions for prolonged bleeding in cases where medical interventions are inevitable in these patients.en_US
dc.identifier.citationAkdeniz, N., Karakuş, A., Yıldiz, İ. ve Ayyıldız, M.O. (2021). Evaluation of bleeding symptoms and laboratory parameters related to bleeding in sisters of patients with hemophilia A and B. Transfusion and Apheresis Science, 60(29), 1-7. http://doi.org/10.1016/j.transci.2020.103044en_US
dc.identifier.doi10.1016/j.transci.2020.103044
dc.identifier.endpage7en_US
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue2en_US
dc.identifier.pmid33390328
dc.identifier.scopus2-s2.0-85098644877
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1473050220303773?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/10100
dc.identifier.volume60en_US
dc.identifier.wosWOS:000636456800011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarakuş, Abdullah
dc.institutionauthorYıldız, İsmail
dc.institutionauthorAyyıldız, Mehmet Orhan
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science LTDen_US
dc.relation.ispartofTransfusion and Apheresis Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemophiliaen_US
dc.subjectSisters of patients with hemophiliaen_US
dc.subjectClotting factoren_US
dc.subjectBleeding tendencyen_US
dc.subjectSeverity of hemophiliaen_US
dc.titleEvaluation of bleeding symptoms and laboratory parameters related to bleeding in sisters of patients with hemophilia A and Ben_US
dc.titleEvaluation of bleeding symptoms and laboratory parameters related to bleeding in sisters of patients with hemophilia A and B
dc.typeArticleen_US

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